重症监护病房营养对微生物组和患者结局的影响。
Impact of Intensive Care Unit Nutrition on the Microbiome and Patient Outcomes.
机构信息
Department of Anesthesiology, Duke University Hospital, 2301 Erwin Road, Box #3094, Durham, NC 27710, USA.
Department of Anesthesiology and Perioperative Medicine, University of Alabama at Birmingham, 950 Jefferson Tower, 625 19th Street South, Birmingham, AL 35249-6810, USA.
出版信息
Anesthesiol Clin. 2023 Mar;41(1):263-281. doi: 10.1016/j.anclin.2022.10.007.
The bipartite relationship between nutrition and the intestinal microbiome represents an exciting frontier in critical care medicine. In this review, the authors first address these topics independently, leading with a summary of recent clinical studies assessing intensive care unit nutritional strategies, followed by an exploration of the microbiome in the context of perioperative and intensive care, including recent clinical data implicating microbial dysbiosis as a key driver of clinical outcomes. Finally, the authors address the intersection of nutrition and the microbiome, exploring the use of supplemental pre-, pro-, and synbiotics to influence microbial composition and improve outcomes in critically ill and postsurgical patients.
营养与肠道微生物组之间的双重关系代表了重症医学领域的一个令人兴奋的前沿。在这篇综述中，作者首先分别讨论了这些主题，首先总结了最近评估重症监护病房营养策略的临床研究，然后探讨了围手术期和重症监护中的微生物组，包括最近的临床数据表明微生物失调是临床结果的关键驱动因素。最后，作者讨论了营养与微生物组的交叉点，探讨了使用补充预、益生菌和合生菌来影响微生物组成并改善重症和手术后患者的预后。
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