Kaneto H, Kaneda H, Kawatani S
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Nagasaki University, Japan.
Yakubutsu Seishin Kodo. 1987 Jun;7(2):327-32.
To confirm our previous finding that the underlying mechanism for the development of physical dependence on alcohol and barbital are fundamentally different from each other, further studies on the effect of drugs that modify neurotransmission on the alcohol and barbital withdrawal signs were carried out in alcohol and barbital dependent mice. Phentolamine, propranolol and methysergide exacerbated the alcohol withdrawal signs but suppressed the barbital withdrawal signs indicating the qualitative difference of the underlying mechanism. Some quantitative differences were also found in the effect of clonidine, prazosin, yohimbine, muscimol and bicuculline. On the other hand, metoprolol, atropine and scopolamine did not affect the withdrawal signs developed in the alcohol and barbital dependent animals at the dose employed in the present experiment. These results indicate that the withdrawal signs that appear in alcohol and barbital dependent animals are the manifestation of functional abnormalities of the nervous system, and alcohol and barbital dependence rely on different mechanisms for their production.
为了证实我们之前的发现，即对酒精和巴比妥产生身体依赖的潜在机制根本不同，我们在对酒精和巴比妥产生依赖的小鼠身上，进一步研究了改变神经传递的药物对酒精和巴比妥戒断症状的影响。酚妥拉明、普萘洛尔和甲基麦角新碱加剧了酒精戒断症状，但抑制了巴比妥戒断症状，这表明潜在机制存在质的差异。在可乐定、哌唑嗪、育亨宾、蝇蕈醇和荷包牡丹碱的作用方面也发现了一些量的差异。另一方面，在本实验所采用的剂量下，美托洛尔、阿托品和东莨菪碱并未影响酒精和巴比妥依赖动物出现的戒断症状。这些结果表明，酒精和巴比妥依赖动物出现的戒断症状是神经系统功能异常的表现，酒精和巴比妥依赖的产生依赖于不同的机制。
