Wei Jinwu, Wang Mingxia, Li Guixiang
The Second Clinical Medical College, Lanzhou University, Lanzhou, Gansu, China.
Cancer Center, Lanzhou University Second Hospital, Lanzhou, Gansu, China.
Front Oncol. 2023 Feb 17;13:1048922. doi: 10.3389/fonc.2023.1048922. eCollection 2023.
To systematically evaluate the relationship between cancer-associated fibroblasts (CAFs) and clinicopathological characteristics and prognosis of gastric cancer, so as to provide new directions and clinical evidence for the diagnosis and treatment of this disease.
We searched PubMed, Embase, Web of Science, and The Cochrane Library to identify studies on the correlation between tumor-associated fibroblasts and the diagnosis and prognosis of gastric cancer. Two researchers screened the literature independently to extract data, evaluated the quality of the included studies, and used the Review Manager 5.4 software to perform a meta-analysis.
A total of 14 studies involving a total of 2,703 patients were included. The meta-analysis results showed that high expression of CAFs was associated with stage III-IV gastric cancer (relative risk ratio [RR]=1.59; 95% confidence interval [CI]: [1.24-2.04]; P=0.0003), lymph node metastasis (RR=1.51; 95% CI: [1.23-1.87]; P=0.0001), serosal infiltration (RR=1.56, 95% CI: [1.24-1.95]; P=0.0001), diffuse and mixed types in Lauren classification (RR=1.43; 95% CI: [1.18-1.74]; P=0.0003), vascular invasion (RR=1.99; 95% CI: [1.26-3.14]; P=0.003), and overall survival (hazard ratio [HR]=1.38; 95% CI: [1.22-1.56]; P<0.00001). However, the high expression of CAFs was not significantly correlated with poorly differentiated gastric cancer (RR=1.03; 95% CI: [0.96-1.10]; P=0.45) and gastric cancer with tumor diameter >5 cm (RR=1.34; 95% CI: [0.98-1.83]; P=0.07).
The findings of this meta-analysis demonstrated that high expression of CAFs is closely associated with the traditional pathological indicators related to poor prognosis in gastric cancer, and is a valuable prognostic factor in this setting.
https://www.crd.york.ac.uk/PROSPERO/, identifier CRD42022358165.
系统评价癌症相关成纤维细胞（CAFs）与胃癌临床病理特征及预后的关系，为该病的诊断和治疗提供新方向及临床依据。
检索PubMed、Embase、Web of Science和Cochrane图书馆，以确定关于肿瘤相关成纤维细胞与胃癌诊断及预后相关性的研究。两名研究人员独立筛选文献以提取数据，评估纳入研究的质量，并使用Review Manager 5.4软件进行荟萃分析。
共纳入14项研究，涉及2703例患者。荟萃分析结果显示，CAFs高表达与Ⅲ - Ⅳ期胃癌（相对危险比[RR]=1.59；95%置信区间[CI]：[1.24 - 2.04]；P = 0.0003）、淋巴结转移（RR = 1.51；95% CI：[1.23 - 1.87]；P = 0.0001）、浆膜浸润（RR = 1.56，95% CI：[1.24 - 1.95]；P = 0.0001）、Lauren分类中的弥漫型和混合型（RR = 1.43；95% CI：[1.18 - 1.74]；P = 0.0003）、血管侵犯（RR = 1.99；95% CI：[1.26 - 3.14]；P = 0.003）及总生存期（风险比[HR]=1.38；95% CI：[1.22 - 1.56]；P < 0.00001）相关。然而，CAFs高表达与低分化胃癌（RR = 1.03；95% CI：[0.96 - 1.10]；P = 0.45）及肿瘤直径>5 cm的胃癌（RR = 1.34；95% CI：[0.98 - 1.83]；P = 0.07）无显著相关性。
该荟萃分析结果表明，CAFs高表达与胃癌预后不良相关的传统病理指标密切相关，是该情况下有价值的预后因素。
