Han Le, Tan Bingyao, Schmetterer Leopold, Bizheva Kostadinka
Department of Physics and Astronomy, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada.
School of Chemistry, Chemical Engineering and Biotechnology, Nanyang Technological University, 639798, Singapore.
Biomed Opt Express. 2023 Jan 26;14(2):883-905. doi: 10.1364/BOE.484257. eCollection 2023 Feb 1.
A novel decorrelation-based approach for measuring localized transverse flow velocity using line-scan (LS) optical coherence tomography (OCT) is proposed. The new approach allows for separation of the flow velocity component along the line-illumination direction of the imaging beam from other orthogonal velocity components, from particle diffusion motion, and from noise-induced distortion in the OCT signal's temporal autocorrelation. The new method was verified by imaging flow in a glass capillary and a microfluidic device and mapping the spatial distribution of the flow velocity within the beam's illumination plane. This method can be extended in the future to map the three-dimensional flow velocity fields for both ex and applications.
提出了一种基于去相关的新颖方法，用于使用线扫描（LS）光学相干断层扫描（OCT）测量局部横向流速。这种新方法能够将沿成像光束线照明方向的流速分量与其他正交速度分量、粒子扩散运动以及OCT信号时间自相关中的噪声引起的失真分离开来。通过对玻璃毛细管和微流控装置中的流动进行成像，并绘制光束照明平面内流速的空间分布，验证了该新方法。未来，这种方法可扩展用于绘制体内和体外应用的三维流速场。
