Department of Small Animal Clinical Sciences, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada.
Can Vet J. 2023 Mar;64(3):245-251.
In humans, post-traumatic hypopituitarism (PTHP) is a common complication of traumatic brain injury, with the most frequently reported hormonal deficiencies resulting in hyposomatotropism and hypogonadism, followed by hypothyroidism, hypocortisolism, and central diabetes insipidus. To date, PTHP has rarely been reported in cats, and the reported cases often describe a single hormone deficiency. This report details an approximately 7-month-old cat with a history of suspected traumatic brain injury at 5 wk of age, that presented with growth retardation (1.53 kg) and polyuria-polydipsia. Thyroid panel, thyrotropin-releasing hormone stimulation test, thyroid scan with Technetium-99, repeat measurement of serum IGF-1, resting cortisol, endogenous ACTH concentration, and ACTH stimulation testing were performed. The cat was diagnosed with presumptive PTHP leading to hyposomatotropism, hypothyroidism, central diabetes insipidus, and hypogonadism. In this case, treatment of the hypothyroidism and central diabetes insipidus were successful. Hyposomatotropism and hypogonadism were not treated. Although reported feline PTHP cases have described a single hormone deficiency, this report details a cat with presumptive PTHP leading to hyposomatotropism, hypothyroidism, central diabetes insipidus, and hypogonadism. Attention should be paid to the potential for the development of PTHP in cats secondary to traumatic brain injury. Key clinical message: Post-traumatic hypopituitarism in cats can lead to multiple hormone deficiencies, leading to hyposomatotropism, hypothyroidism, central diabetes insipidus, and hypogonadism.
在人类中，创伤后垂体功能减退症（PTHP）是创伤性脑损伤的常见并发症，最常报道的激素缺乏导致生长激素缺乏症和性腺功能减退症，其次是甲状腺功能减退症、皮质醇缺乏症和中枢性尿崩症。迄今为止，猫中很少报道 PTHP，并且报道的病例通常描述单一激素缺乏。本报告详细介绍了一例约 7 月龄的猫，该猫在 5 周龄时疑似创伤性脑损伤，表现为生长迟缓（1.53 公斤）和多尿多饮。进行了甲状腺功能检测、促甲状腺素释放激素刺激试验、甲状腺扫描（使用锝-99）、血清 IGF-1 重复测量、静息皮质醇、内源性 ACTH 浓度和 ACTH 刺激试验。该猫被诊断为疑似 PTHP 导致生长激素缺乏症、甲状腺功能减退症、中枢性尿崩症和性腺功能减退症。在这种情况下，甲状腺功能减退症和中枢性尿崩症的治疗取得了成功。生长激素缺乏症和性腺功能减退症未进行治疗。尽管报道的猫 PTHP 病例描述了单一激素缺乏，但本报告详细介绍了一例疑似 PTHP 导致生长激素缺乏症、甲状腺功能减退症、中枢性尿崩症和性腺功能减退症的猫。应注意创伤性脑损伤后猫发生 PTHP 的可能性。关键临床信息：猫的创伤后垂体功能减退症可导致多种激素缺乏，导致生长激素缺乏症、甲状腺功能减退症、中枢性尿崩症和性腺功能减退症。
