Systems Medicine, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
Immunogenomics and Neurodegeneration, Deutsches Zentrum für Neurodegenerative Erkrankungen (DZNE), Bonn, Germany.
Front Immunol. 2023 Feb 16;14:1108716. doi: 10.3389/fimmu.2023.1108716. eCollection 2023.
The COVID-19 pandemic has shown the potentially devastating impact of novel respiratory infections worldwide. Insightful data obtained in the last years have shed light on the pathophysiology of SARS-CoV-2 infection and the role of the inflammatory response in driving both the resolution of the disease and uncontrolled deleterious inflammatory status in severe cases. In this mini-review, we cover some important aspects of the role of T cells in COVID-19 with a special focus on the local response in the lung. We focus on the reported T cell phenotypes in mild, moderate, and severe COVID-19, focusing on lung inflammation and on both the protective and damaging roles of the T cell response, also highlighting the open questions in the field.
新冠疫情表明，新型呼吸道感染可能在全球范围内造成破坏性影响。过去几年获得的有见地的数据揭示了 SARS-CoV-2 感染的病理生理学机制，以及炎症反应在驱动疾病消退和重症病例中失控性有害炎症状态中的作用。在这篇简评中，我们将介绍 T 细胞在 COVID-19 中的作用的一些重要方面，特别关注肺部的局部反应。我们重点介绍了在轻症、中症和重症 COVID-19 中报告的 T 细胞表型，聚焦于肺部炎症以及 T 细胞反应的保护和损伤作用，并突出了该领域的悬而未决的问题。
