Chemical constituents from aerial parts of .

OBJECTIVE

To study the chemical constituents from the aerial parts of .

METHODS

Various chromatographic techniques were used to separate the constituents and their structures were elucidated using spectroscopic methods and by comparing their data to those reported in the literatures. The -glucosidase inhibitory activity assay was used to identify potential -glucosidase inhibitors.

RESULTS

Nine compounds were isolated from the aerial parts of . Their structures were identified as Scoparic zolone (), (2)-2,7-dihydroxy-2-1,4-benzoxazin-3(4)-one (), (2)-7-hydroxy-2-1,4-benzoxazin-3(4)-one-2----glucopyranoside (), (2)-7-methoxy-2-1,4-benzoxazin-3(4)-one-2----glucopyranoside (), (2)-7-hydroxy-2-1,4-benzoxazin-3(4)-one-2----glucopyranoside (), 6-methoxy-benzoxazolin-2(3)-one (), 4-acetonyl-3,5-dimethoxy--quinol (), zizyvoside I (), and 3,4-dihydroxy benzeneacetic acid (). Compound showed the potent α-glucosidase inhibitory activity with an IC value of (132.8 ± 11.5) μmol/L, which is 28-fold higher than the positive control acarbose.

CONCLUSION

Compound is a new natural product. Compounds and have not been reported in Scoparia before. Compounds , , , are isolated from Scrophulariaceae for the first time.