Bratisl Lek Listy. 2023;124(5):380-386. doi: 10.4149/BLL_2023_058.
We performed this meta-analysis determining the antihypertensive effect of telmisartan versus perindopril in patients with essential hypertension.
The comparison of antihypertensive effects between telmisartan and perindopril were controversial.
Pubmed, Web of Science, and Cochrane Central were searched for all published studies.
The antihypertensive effects were assessed in 753 patients included in 7 trials with a mean follow-up of 20 ± 16 weeks. There was no significant difference between telmisartan and perindopril in reduction of systolic blood pressure (SBP, weighted mean differences (WMD) 0.02 (95% confidence interval (CI), ‒2.78, 2.81) mm Hg, p > 0.05). The reduction of diastolic BP (DBP) treated with telmisartan was greater than perindopril in these patients (WMD ‒2.05 (95% CI, ‒2.60, ‒1.49) mm Hg, p < 0.001). Considering the effects of different doses on BP reduction, a sub-analysis was performed. The reduction of DBP treated with 40 mg/day telmisartan was greater than 4‒5 mg/day perindopril (WMD ‒2.18 (95% CI, ‒2.83, ‒1.53) mm Hg, p 0.05).
The reduction of DBP is greater treated with telmisartan than perindopril in patients with essential hypertension (Tab. 2, Fig. 4, Ref. 34). Text in PDF www.elis.sk Keywords: essential hypertension, blood pressure, telmisartan, perindopril, meta-analysis.
本荟萃分析旨在确定替米沙坦与培哚普利在原发性高血压患者中的降压效果。
替米沙坦与培哚普利降压效果的比较存在争议。
检索 Pubmed、Web of Science 和 Cochrane Central 以获取所有已发表的研究。
纳入的 7 项试验共 753 例患者的降压效果评估，平均随访 20±16 周。替米沙坦与培哚普利降压效果比较无显著差异（收缩压的加权均数差值为 0.02（95%置信区间，-2.78，2.81）mmHg，p＞0.05）。在这些患者中，替米沙坦降低舒张压的效果大于培哚普利（舒张压的加权均数差值为-2.05（95%置信区间，-2.60，-1.49）mmHg，p＜0.001）。考虑到不同剂量对血压降低的影响，进行了亚组分析。40mg/天替米沙坦降低舒张压的效果大于 4-5mg/天培哚普利（舒张压的加权均数差值为-2.18（95%置信区间，-2.83，-1.53）mmHg，p＜0.05）。
在原发性高血压患者中，替米沙坦降低舒张压的效果大于培哚普利（表 2，图 4，参考文献 34）。
