综述：抑制素在动物生殖系统中的作用及调控机制

Review: Role and regulatory mechanism of inhibin in animal reproductive system.

作者信息

Han Yuqing, Jiang Ting, Shi Jun'an, Liu Anfang, Liu Lingbin

机构信息

College of Animal Science and Technology, Southwest University, Beibei, 400715, Chongqing, China.

出版信息

Theriogenology. 2023 May;202:10-20. doi: 10.1016/j.theriogenology.2023.02.016. Epub 2023 Feb 27.

DOI:10.1016/j.theriogenology.2023.02.016

PMID:36878034

Abstract

Inhibin (INH) is a glycoprotein hormone secreted by the gonads that inhibit the synthesis and secretion of follicle-stimulating hormone (FSH). Increasing evidence indicates that INH plays a significant role in the development of the reproductive system including follicle development, ovulation rate, corpus luteum formation and ablation, steroid hormone synthesis and spermatogenesis, subsequently affecting the reproductive capacity of animals such as litter size and egg production. There are currently three main views on how INH inhibits FSH synthesis and secretion: influencing the activity of adenylate cyclase, the expression of follicle-stimulating hormone receptor or gonadotropin-releasing hormone receptor, and the competition system of inhibin-activin. This review discusses the current findings on the structure, function, and mechanism of action of INH in the reproductive system of animals.

摘要

抑制素（INH）是一种由性腺分泌的糖蛋白激素，可抑制促卵泡激素（FSH）的合成与分泌。越来越多的证据表明，抑制素在生殖系统发育中发挥着重要作用，包括卵泡发育、排卵率、黄体形成与退化、类固醇激素合成以及精子发生，随后影响动物的繁殖能力，如产仔数和产蛋量。目前关于抑制素如何抑制FSH合成与分泌主要有三种观点：影响腺苷酸环化酶的活性、促卵泡激素受体或促性腺激素释放激素受体的表达，以及抑制素-激活素竞争系统。本文综述了抑制素在动物生殖系统中的结构、功能及作用机制的当前研究结果。