天然存在的二肽和单链寡核苷酸对耐药性HIV-1的协同抗病毒活性。
Synergistic antiviral activity against drug-resistant HIV-1 by naturally occurring dipeptide and A single-stranded oligonucleotide.
作者信息
Ceña-Diez Rafael, Spetz Anna-Lena, Sönnerborg Anders
机构信息
Division of Infectious Diseases/ANA Futura, Department of Medicine Huddinge, Karolinska Institutet, Alfred Nobels Allé 8, 141 52 Huddinge, Sweden.
Department of Molecular Biosciences, Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.
出版信息
Drug Resist Updat. 2023 May;68:100955. doi: 10.1016/j.drup.2023.100955. Epub 2023 Mar 4.
The novel dipeptide WG-am and single-stranded oligonucleotide combination (WG-am:ssON) showed synergistic antiviral activity against HIV-1 integrase-, protease- or reverse transcriptase drug resistant isolates, with over 95% reduction. The highest selectivity indexes were for integrase resistant isolates. WG-am:ssON can be a future option for treatment of HIV drug-resistant strains.
新型二肽WG-am与单链寡核苷酸组合（WG-am:ssON）对HIV-1整合酶、蛋白酶或逆转录酶耐药分离株显示出协同抗病毒活性，病毒载量降低超过95%。整合酶耐药分离株的选择性指数最高。WG-am:ssON可能成为治疗HIV耐药菌株的未来选择。
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