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黄芩苷镁通过抑制 NLRP3/Caspase-1/IL-1β 信号通路对非酒精性脂肪性肝炎大鼠发挥保护作用。

Protective effecs of baicalin magnesium on non-alcoholic steatohepatitis rats are based on inhibiting NLRP3/Caspase-1/IL-1β signaling pathway.

机构信息

Hebei Province Key Laboratory of Research and Development for Chinese Medicine, Institute of Traditional Chinese Medicine, Chengde Medical College, Anyuan Road, Shuangqiao District, Chengde, 067000, Hebei Province, China.

Heibei North University, Zhangjiakou, 075000, China.

出版信息

BMC Complement Med Ther. 2023 Mar 6;23(1):72. doi: 10.1186/s12906-023-03903-2.

DOI:10.1186/s12906-023-03903-2
PMID:36879310
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9987046/
Abstract

Baicalin magnesium is a water-soluble compound isolated from the aqueous solution by Scutellaria baicalensis Georgi. Preliminary experiments have demonstrated that baicalin magnesium can exert protective effects against acute liver injury in rats induced by carbon tetrachloride or lipopolysaccharide combined with d-galactose by regulating lipid peroxidation and oxidative stress. The aim of this study was to investigate the protective effect of baicalin magnesium on non-alcoholic steatohepatitis (NASH) in rats and to elucidate the underlying mechanisms. NASH was induced through a high-fat diet (HFD) for 8 weeks, and Sprague-Dawley rats were intravenously injected with baicalin magnesium, baicalin, and magnesium sulfate for 2 weeks, respectively. Serum was obtained for biochemical analyses and the determination of oxidative stress indicators. Liver tissues were collected for use in liver index assessment, histopathological examination, inflammatory factor analysis, and protein and gene expression analysis. The results revealed that baicalin magnesium markedly improved HFD-induced lipid deposition, inflammatory response, oxidative stress, and histopathological impairments. And baicalin magnesium may exert a protective effect on NASH rats by inhibiting the NLR family pyrin domain involving the 3 (NLRP3)/caspase-1/interleukin (IL)-1β inflammatory pathway. Additionally, the effect of baicalin magnesium was remarkably superior to that of equimolar baicalin and magnesium sulfate in regard to ameliorating NASH symptoms. In conclusion, the findings suggested that baicalin magnesium may represent a potential drug for the treatment of NASH.

摘要

黄芩镁是从黄芩的水溶液中分离得到的一种水溶性化合物。初步实验表明，黄芩镁通过调节脂质过氧化和氧化应激，对四氯化碳或脂多糖联合半乳糖诱导的大鼠急性肝损伤具有保护作用。本研究旨在探讨黄芩镁对非酒精性脂肪性肝炎（NASH）大鼠的保护作用，并阐明其作用机制。通过 8 周高脂肪饮食（HFD）诱导 NASH，分别对 Sprague-Dawley 大鼠静脉注射黄芩镁、黄芩和硫酸镁 2 周。收集血清进行生化分析和氧化应激指标测定。收集肝组织进行肝指数评估、组织病理学检查、炎症因子分析以及蛋白和基因表达分析。结果表明，黄芩镁显著改善了 HFD 诱导的脂质沉积、炎症反应、氧化应激和组织病理学损伤。黄芩镁可能通过抑制富含亮氨酸重复序列的 NLR 家族蛋白 3（NLRP3）/半胱氨酸天冬氨酸蛋白酶-1（caspase-1）/白细胞介素（IL）-1β炎症通路，对 NASH 大鼠发挥保护作用。此外，黄芩镁在改善 NASH 症状方面的效果明显优于等摩尔黄芩镁和硫酸镁。综上所述，研究结果表明，黄芩镁可能是治疗 NASH 的潜在药物。

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