肾衰竭患者氯磺丙脲过量：用活性炭血液灌流治疗

Chlorpropamide overdose in renal failure: management with charcoal hemoperfusion.

作者信息

Ludwig S M, McKenzie J, Faiman C

机构信息

Department of Internal Medicine, University of Manitoba, Winnipeg, Canada.

出版信息

Am J Kidney Dis. 1987 Dec;10(6):457-60. doi: 10.1016/s0272-6386(87)80193-2.

DOI:10.1016/s0272-6386(87)80193-2

PMID:3687936

Abstract

A potentially lethal chlorpropamide overdose in a patient with chronic renal failure on long-term hemodialysis was treated by two courses of charcoal hemoperfusion. Hemoperfusion shortened the half-life clearance of the drug from a mean value of 93.6 to 3.4 hours. Calculation of the fractional extraction indicated that hemoperfusion reduced the body burden of the drug by 24% and 19% (mean values) during the first and second hours of treatment, respectively. We conclude that charcoal hemoperfusion should be considered a definitive therapeutic option in such cases.

摘要

一名长期接受血液透析的慢性肾衰竭患者发生了可能致命的氯磺丙脲过量中毒，通过两个疗程的活性炭血液灌流进行治疗。血液灌流将药物的半衰期清除率从平均93.6小时缩短至3.4小时。分数提取计算表明，在治疗的第一小时和第二小时，血液灌流分别将药物的体内负荷降低了24%和19%（平均值）。我们得出结论，在这种情况下，活性炭血液灌流应被视为一种确定性的治疗选择。