染色体异常大鼠掌垫上的皮纹发育
Dermatoglyphic development on the volar pads of rats with chromosome abnormalities.
作者信息
Okajima M, Yosida T H, Ikeuchi T
机构信息
Department of Forensic Medicine, Tokyo Medical and Dental University, Japan.
出版信息
Am J Med Genet. 1987 Dec;28(4):1007-13. doi: 10.1002/ajmg.1320280428.
Dermatoglyphic abnormalities are often observed in patients with chromosome aberrations, but no similar observations have been made in animals. In the present study, palmar dermatoglyphics were examined in 4 rats with chromosome anomalies. Reciprocal translocations were induced by gamma-irradiation; the animals used were obtained from among offspring with abnormal karyotypes that were derived from the original mutant rats. As the epidermal surface of the volar pad of the rat is flat, dermatoglyphic characteristics were observed on the dermal surface following staining with toluidine blue. Unusual ridge configurations were found in some of them, suggesting that dermatoglyphic development in the rat reflects, to some extent, an abnormal chromosome constitution.
在染色体畸变患者中常观察到皮纹异常，但在动物中尚未有类似观察结果。在本研究中，对4只患有染色体异常的大鼠进行了手掌皮纹检查。通过γ射线照射诱导相互易位；所用动物取自源自原始突变大鼠的核型异常后代。由于大鼠掌垫的表皮表面是平的，在用甲苯胺蓝染色后在真皮表面观察到皮纹特征。在其中一些大鼠中发现了异常的嵴形态，这表明大鼠的皮纹发育在一定程度上反映了异常的染色体组成。
Zotero 插件