不仅仅是一种组蛋白脱乙酰酶：细胞质中的SIRT6通过使ACSL5去乙酰化促进脂肪酸氧化。 - Suppr

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超能文献

More than just a histone deacetylase: cytoplasmic SIRT6 facilitates fatty acid oxidation through ACSL5 deacetylation.

作者信息

Li Shuoshuo, Yuan Zengqiang

出版信息

Acta Biochim Biophys Sin (Shanghai). 2023 Mar 25;55(3):525-527. doi: 10.3724/abbs.2023030.

DOI:10.3724/abbs.2023030

PMID:36880305

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10160229/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4f55/10160229/22fb3d4ec016/ABBS-2022-654-t1.jpg

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本文引用的文献

Cytoplasmic SIRT6-mediated ACSL5 deacetylation impedes nonalcoholic fatty liver disease by facilitating hepatic fatty acid oxidation.

Mol Cell. 2022 Nov 3;82(21):4099-4115.e9. doi: 10.1016/j.molcel.2022.09.018. Epub 2022 Oct 7.

Mechanisms of NAFLD development and therapeutic strategies.

Nat Med. 2018 Jul;24(7):908-922. doi: 10.1038/s41591-018-0104-9. Epub 2018 Jul 2.

Mitochondrial Adaptation in Nonalcoholic Fatty Liver Disease: Novel Mechanisms and Treatment Strategies.

Trends Endocrinol Metab. 2017 Apr;28(4):250-260. doi: 10.1016/j.tem.2016.11.006. Epub 2016 Dec 13.

Partitioning circadian transcription by SIRT6 leads to segregated control of cellular metabolism.

Cell. 2014 Jul 31;158(3):659-72. doi: 10.1016/j.cell.2014.06.050.

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21.

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SIRT6 regulates TNF-α secretion through hydrolysis of long-chain fatty acyl lysine.

Nature. 2013 Apr 4;496(7443):110-3. doi: 10.1038/nature12038.

Hepatic-specific disruption of SIRT6 in mice results in fatty liver formation due to enhanced glycolysis and triglyceride synthesis.

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Transcriptional activation of hepatic ACSL3 and ACSL5 by oncostatin m reduces hypertriglyceridemia through enhanced beta-oxidation.

Arterioscler Thromb Vasc Biol. 2007 Oct;27(10):2198-205. doi: 10.1161/ATVBAHA.107.148429. Epub 2007 Aug 30.

Genomic instability and aging-like phenotype in the absence of mammalian SIRT6.

Cell. 2006 Jan 27;124(2):315-29. doi: 10.1016/j.cell.2005.11.044.

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