SIRT6：非酒精性脂肪性肝病的治疗靶点。
SIRT6: therapeutic target for nonalcoholic fatty liver disease.
机构信息
Barshop Institute for Longevity and Aging Studies, Center for Healthy Aging, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Department of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX 78229, USA; Geriatric Research, Education and Clinical Center, South Texas Veterans Health Care System, San Antonio, TX 78229, USA.
Laboratory of Liver Diseases, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD 20892, USA.
出版信息
Trends Endocrinol Metab. 2022 Dec;33(12):801-803. doi: 10.1016/j.tem.2022.10.004. Epub 2022 Nov 1.
Abstract
Recently, Hou et al. shifted the research focus from the function of nuclear sirtuin (SIRT)6 to that of cytoplasmic SIRT6, which deacetylates and activates long-chain acyl-CoA synthase 5 (ACSL5). Their findings provide mechanistic insight into the role of cytoplasmic SIRT6 in fatty acid oxidation, acting as a therapeutic target for combating nonalcoholic fatty liver disease (NAFLD).
摘要
最近，侯等人将研究重点从核 SIRT6 的功能转移到细胞质 SIRT6，细胞质 SIRT6 可以使长链酰基辅酶 A 合成酶 5（ACSL5）去乙酰化并激活。他们的发现为细胞质 SIRT6 在脂肪酸氧化中的作用提供了机制上的见解，可作为治疗非酒精性脂肪性肝病（NAFLD）的靶点。
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