Department of Midwifery, Shiraz University of Medical Sciences School of Nursing and Midwifery, Shiraz, Iran (the Islamic Republic of).
Department of Midwifery, Islamic Azad University of Estahban, Estahban, Iran (the Islamic Republic of)
BMJ Open. 2023 Mar 7;13(3):e060483. doi: 10.1136/bmjopen-2021-060483.
Vitamin D is associated with many functions of the human reproductive system. Accordingly, it seems that on infertile couples undergoing assisted reproduction technology (ART), treatment outcomes may be affected by the vitamin D. This overview aims to show the effect of vitamin D on infertility treatments outcomes in recent studies by concluding systematic reviews and meta-analyses to achieve a comprehensive result.
This overview protocol is being reported according to the Preferred Reporting Items for Systematic review and Meta-Analysis Protocols (PRISMA-P) statement and was registered in the International Prospective Register of Systematic Reviews. We will include all peer-reviewed systematic reviews and meta-analyses of randomised controlled trials published from inception until December 2022. PubMed, Web of Science, Cochrane Database of Systematic Reviews, Cochrane Database of Abstracts of Reviews of Effects, Scopus, Cochrane Central Register of Controlled Trials and Embase will be searched from the time of publication of the first articles onwards with a comprehensive search strategy. Endnote V.X7 software (Thomson Reuters, New York, New York, USA) will be used to store and manage records. The results will align with guidelines in the Cochrane Handbook of Systematic Reviews of Interventions and the PRISMA statement.
This overview will be evaluating the effect of vitamin D status and vitamin D supplementing on results of ART in women and men who are undergoing treatment for infertility. The high prevalence of vitamin D deficiency worldwide and its effects on an important issue such as human fertility might be a very influential factor that leads scientists to strongly recommend its use. However, the more critical concern is that there is no definitive agreement in studies on the relationship between vitamin D and an increased chance of better fertility in men and women undergoing infertility treatment.
CRD42021252752.
维生素 D 与人体生殖系统的许多功能有关。因此，在接受辅助生殖技术（ART）的不孕夫妇中，维生素 D 似乎会影响治疗结果。本综述旨在通过总结系统评价和荟萃分析来得出综合结果，展示最近研究中维生素 D 对不孕治疗结果的影响。
本综述方案按照系统评价和荟萃分析优先报告项目（PRISMA-P）声明进行报告，并在国际前瞻性系统评价注册库中进行了注册。我们将纳入所有关于维生素 D 对随机对照试验的系统评价和荟萃分析，这些研究自发表以来一直持续到 2022 年 12 月。将从第一篇文章发表开始，通过全面的搜索策略，在 PubMed、Web of Science、Cochrane 系统评价数据库、Cochrane 疗效评价文摘数据库、Scopus、Cochrane 对照试验中心注册库和 Embase 中进行搜索。Endnote V.X7 软件（Thomson Reuters，纽约，美国）将用于存储和管理记录。结果将与 Cochrane 干预措施系统评价手册和 PRISMA 声明中的指南保持一致。
本综述将评估维生素 D 状态和维生素 D 补充对接受不孕治疗的女性和男性的 ART 结果的影响。维生素 D 缺乏在全球的高患病率及其对人类生育等重要问题的影响可能是一个非常有影响力的因素，促使科学家强烈建议使用它。然而，更关键的问题是，在研究维生素 D 与接受不孕治疗的男性和女性生育能力提高的机会之间的关系时，并没有达成明确的一致意见。
CRD42021252752。
