Zhou Yanyan, Luo Xiang, Wang Zhixin, McClements David Julian, Huang Wenna, Fu Hongliang, Zhu Kewu
Center for Drug Delivery System Research, School of Medicine, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China.
Center for Drug Delivery System Research, School of Medicine, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China; Zhejiang Engineering Research Center of Fat-soluble Vitamin, School of Chemistry and Chemical Engineering, Shaoxing University, 900 Chengnan Avenue, Shaoxing, Zhejiang 312000, China.
Food Chem. 2023 Aug 1;416:135776. doi: 10.1016/j.foodchem.2023.135776. Epub 2023 Mar 1.
α-Tocopherol, as an oil-soluble vitamin with strong antioxidant activity. It is the most naturally abundant and biologically active form of vitamin E in humans. In this study, a novel emulsifier (PG20-VES) was synthesized by attaching hydrophilic twenty-polyglycerol (PG20) to hydrophobic vitamin E succinate (VES). This emulsifier was shown to have a relatively low critical micelle concentration (CMC = 3.2 μg/mL). The antioxidant activities and emulsification properties of PG20-VES were compared with those of a widely used commercial emulsifier: D-α-Tocopherol polyethylene glycol 1000 succinate (TPGS). PG20-VES exhibited a lower interfacial tension, stronger emulsifying capacity and similar antioxidant property to TPGS. An in vitro digestion study showed that lipid droplets coated by PG20-VES were digested under simulated small intestine conditions. This study showed that PG20-VES is an efficient antioxidant emulsifier, which may have applications in the formulation of bioactive delivery systems in the food, supplement, and pharmaceutical industries.
α-生育酚是一种具有强抗氧化活性的脂溶性维生素。它是人体内维生素E最天然丰富且具有生物活性的形式。在本研究中，通过将亲水性的二十聚甘油（PG20）连接到疏水性的维生素E琥珀酸酯（VES）上，合成了一种新型乳化剂（PG20-VES）。该乳化剂显示出相对较低的临界胶束浓度（CMC = 3.2 μg/mL）。将PG20-VES的抗氧化活性和乳化性能与一种广泛使用的商业乳化剂：D-α-生育酚聚乙二醇1000琥珀酸酯（TPGS）进行了比较。PG20-VES表现出更低的界面张力、更强的乳化能力以及与TPGS相似的抗氧化性能。一项体外消化研究表明，由PG20-VES包被的脂质小滴在模拟小肠条件下会被消化。本研究表明，PG20-VES是一种高效的抗氧化乳化剂，可能在食品、补充剂和制药行业的生物活性递送系统配方中具有应用价值。
