酒精中毒保护：必须是 FGF21 进入。

Protection from alcohol intoxication: Must be FGF21 to enter.

机构信息

Department of Molecular Biosciences, The Wenner-Gren Institute, Stockholm University, 106 91 Stockholm, Sweden.

Helmholtz Zentrum München, 85764 Neuherberg, Germany; Division of Metabolic Diseases, Department of Medicine, Technical University of München, Munich, Germany.

出版信息

Cell Metab. 2023 Mar 7;35(3):377-379. doi: 10.1016/j.cmet.2023.02.010.

DOI:10.1016/j.cmet.2023.02.010

PMID:36889276

Abstract

Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in mammals. In this issue of Cell Metabolism, Choi et al. demonstrate that FGF21 mediates the recovery from alcohol intoxication by directly activating noradrenergic neurons in mice, thus advancing our knowledge on FGF21 biology and further diversifying its therapeutic potential.

摘要

成纤维细胞生长因子 21（FGF21）通常被认为是一种应激诱导的代谢调节剂，具有巨大的治疗代谢疾病的潜力，但 FGF21 的一个更具体的作用涉及哺乳动物对酒精的生理处理。在本期《细胞代谢》中，Choi 等人证明 FGF21 通过直接激活小鼠的去甲肾上腺素能神经元来介导酒精中毒的恢复，从而增进了我们对 FGF21 生物学的认识，并进一步使其治疗潜力多样化。