Lee Sinyeong, Yoo Koo Han, Kim Taek Sang, Cho Hyuk Jin, Kim Wansuk, Oh Jin Kyu, Li Shufeng, Kim Sang Youn, Wei Wuran, Huang Jianlin, van Uem Stefanie, Del Giudice Francesco, Lindars David P, Sathe Abha R, Chung Benjamin I
Department of Urology, Stanford University School of Medicine, Stanford, California, USA.
Department of Urology, Seoul Medical Center, Seoul, Korea.
Prostate. 2023 May;83(7):722-728. doi: 10.1002/pros.24509. Epub 2023 Mar 9.
The objective of this study is to analyze characteristics of recurrent acute urinary retention (AUR) in patients with benign prostatic hyperplasia (BPH), utilizing a population based data set. Also, we sought to report on how AUR was treated, specifically regarding the need and length of catheterization and types of procedures utilized for mitigation.
MATERIALS & METHODS: A retrospective observational cohort study was performed using Optum's deidentified Clinformatics® Data Mart Database. We compared two groups, BPH patients with AUR (n = 180,737) and BPH patients without AUR (n = 1,139,760) from January 1, 2003 to December 31, 2017. Also, we analyzed the factors affecting the development of multiple episodes of AUR through age-adjusted multivariate analysis.
In contrast to the 47.7% of patients who had a single AUR episode, 33.5% of AUR patients developed 3 or more subsequent episodes of retention. For age matched patients, the risks of additional episodes of retention increase significantly with older age, Caucasian race, diabetes, neurologic conditions, or low income. Overall, the rate of BPH surgery in AUR patients over the study period decreased and the most common procedure was transurethral resection of the prostate.
Risk factors for multiple episodes of AUR included age (60 and older), Caucasian race, lower income socioeconomic status, diabetes, and neurological disorders. Patients with a high probability of developing recurrent episodes of AUR are recommended to receive preemptive BPH medication before such AUR occurrences. Also, more expeditious surgical treatment should be considered rather than temporary catheterization when AUR occurs.
本研究的目的是利用基于人群的数据集,分析良性前列腺增生(BPH)患者复发性急性尿潴留(AUR)的特征。此外,我们试图报告AUR的治疗方式,特别是关于导尿的必要性、时长以及用于缓解的手术类型。
使用Optum的去识别化临床信息学数据集市数据库进行了一项回顾性观察队列研究。我们比较了2003年1月1日至2017年12月31日期间的两组患者,即患有AUR的BPH患者(n = 180,737)和未患有AUR的BPH患者(n = 1,139,760)。此外,我们通过年龄调整后的多变量分析,分析了影响AUR多次发作的因素。
与47.7%仅有一次AUR发作的患者相比,33.5%的AUR患者随后出现了3次或更多次尿潴留发作。对于年龄匹配的患者,随着年龄增长、白种人、糖尿病、神经系统疾病或低收入,再次出现尿潴留发作的风险显著增加。总体而言,在研究期间,AUR患者的BPH手术率有所下降,最常见的手术是经尿道前列腺切除术。
AUR多次发作的危险因素包括年龄(60岁及以上)、白种人、社会经济地位较低、糖尿病和神经系统疾病。建议有较高复发性AUR发作可能性的患者在AUR发作前接受预防性BPH药物治疗。此外,当AUR发生时,应考虑更迅速的手术治疗而非临时导尿。