Instituto de Biofísica e Engenharia Biomédica, Faculdade de Ciências, Universidade de Lisboa, Lisboa, Portugal.
Instituto Universitário de Lisboa (ISCTE-IUL), CIS-IUL, Lisboa, Portugal.
J Psychopharmacol. 2023 Jun;37(6):566-576. doi: 10.1177/02698811231158233. Epub 2023 Mar 9.
Human social behavior is modulated by oxytocin (OT). Intranasal administration of OT (IN-OT) is a noninvasive route shown to elicit changes in the autonomic nervous system (ANS) activity; however, IN-OT's effect on the temporal profile of ANS activity at rest is yet to be described.
We aimed to describe the temporal profile of IN-OT at six 10-min time windows from 15- to 100-min post-administration in 20 male participants at rest while continuously recording their pupillary in an eyes-open condition and cardiac activity in eyes-open and eyes-closed conditions.
We used a double-blind, placebo-controlled, within-subjects design study where we extracted two proxies of parasympathetic nervous system (PNS) activity: high-frequency heart rate variability (HF-HRV) and pupillary unrest index (PUI); and a proxy of sympathetic nervous system activity: sample entropy of the pupillary unrest.
In the eyes-open condition, we found an effect of IN-OT on the proxies of PNS activity: decreased PUI in the three-time windows post-administration spanning 65-100 min, and as an exploratory finding, an increased HF-HRV in the 80-85 min time window.
We suggest there is a role of OT in PNS regulation that may be consistent with OT's currently theorized role in the facilitation of alertness and approach behavior.
人类的社会行为受催产素（OT）调节。鼻内给予 OT（IN-OT）是一种非侵入性途径，已被证明可以改变自主神经系统（ANS）的活动；然而，IN-OT 对休息时 ANS 活动的时间进程的影响尚未被描述。
我们旨在描述 20 名男性参与者在休息时连续记录瞳孔在睁眼状态下和心脏活动在睁眼和闭眼状态下的情况下，在给药后 15-100 分钟的六个 10 分钟时间窗口内 IN-OT 的时间进程。
我们使用双盲、安慰剂对照、自身对照设计研究，提取副交感神经系统（PNS）活动的两个代理指标：高频心率变异性（HF-HRV）和瞳孔不自主指数（PUI）；以及交感神经系统活动的代理指标：瞳孔不自主的样本熵。
在睁眼状态下，我们发现 IN-OT 对 PNS 活动的代理指标有影响：给药后 65-100 分钟三个时间窗口的 PUI 降低，作为探索性发现，80-85 分钟时间窗口的 HF-HRV 增加。
我们认为 OT 在 PNS 调节中起作用，这可能与 OT 目前在促进警觉和接近行为中的理论作用一致。
