Department of Otolaryngology-Head and Neck Surgery, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Department of Biochemistry, Faculty of Medicine and Graduate School of Medicine, Hokkaido University, Hokkaido, Japan.
Rhinology. 2023 Jun 1;61(3):263-271. doi: 10.4193/Rhin22.405.
Tripartite motif-containing 27 (TRIM27) has been implicated in the progression of various cancers. However, the role of TRIM27 in sinonasal mucosal melanoma (SNMM) remains poorly understood.
MATERIALS & METHODS: We retrospectively examined 28 patients with SNMM treated with between 2003 and 2021. We undertook immunohistochemical analysis of TRIM27, Ki-67, and p-Akt1 expression in SNMM tissues. We also investigated the relationship between TRIM27 expression and clinical characteristics, prognosis, Ki-67 as a tumor growth potential marker, and p-Akt1 as one of the prognostic factors in mucosal melanoma.
TRIM27 expression was significantly higher in T4 disease than in T3 disease and was higher in stage IV than in stage III. Patients with high-TRIM27 SNMM had a significantly poorer prognosis in terms of overall survival (OS) and disease-free survival.There was also a significantly higher rate of distant metastasis. Univariate analysis for OS revealed that TRIM27 and T classification were significant poor prognostic factors. In addition, the Ki-67 positive score and the p-Akt1 total staining score were significantly higher in the high-TRIM27 group than in the low-TRIM27 group.
High TRIM27 expression in SNMM was associated with advanced T classification, poor prognosis and distant metastasis. We suggest that TRIM27 has potential as a novel biomarker for prognosis in SNMM.
三结构域蛋白 27（TRIM27）已被证实与多种癌症的进展有关。然而，TRIM27 在鼻腔鼻窦黏膜黑色素瘤（SNMM）中的作用仍知之甚少。
我们回顾性地研究了 2003 年至 2021 年间接受治疗的 28 例 SNMM 患者。我们对 SNMM 组织中的 TRIM27、Ki-67 和 p-Akt1 表达进行了免疫组织化学分析。我们还研究了 TRIM27 表达与临床特征、预后、Ki-67 作为肿瘤生长潜能标志物以及 p-Akt1 作为黏膜黑色素瘤预后因素之一之间的关系。
TRIM27 在 T4 期疾病中的表达明显高于 T3 期，在 IV 期疾病中的表达明显高于 III 期。高 TRIM27 SNMM 患者的总生存率（OS）和无病生存率明显较差。远处转移率也明显较高。OS 的单因素分析显示，TRIM27 和 T 分类是显著的不良预后因素。此外，高 TRIM27 组的 Ki-67 阳性评分和 p-Akt1 总染色评分明显高于低 TRIM27 组。
SNMM 中高表达的 TRIM27 与晚期 T 分类、不良预后和远处转移有关。我们认为 TRIM27 可能成为 SNMM 预后的一个新的生物标志物。
