Department of Anaesthesia, North Denmark Regional Hospital, Hjørring.
Department of Gastroenterology and Hepatology, Aalborg University Hospital.
Dan Med J. 2023 Jan 17;70(2):A06220393.
Gender difference in the incidence of eosinophilic oesophagitis (EoE) is well-known as more men than women are affected. However, knowledge of gender differences is lacking for most other aspects of EoE. In this population-based adult EoE cohort, the aim was to study if gender differences exist with respect to 1) clinical phenotype, 2) treatment response and 3) complications.
This was a retrospective, registry-based DanEoE cohort study of 236 adult patients with EoE (178 adult men and 58 adult women) diagnosed in 2007-2017 in the North Denmark Region. Medical registries were searched for patient records and pathology reports.
No statistically or clinically significant differences were recorded in the phenotype regarding symptoms reported, macroscopic or histological findings at diagnosis (all p > 0.3). A comparable number of men and women were followed up symptomatically and histologically (all p > 0.3). More men than women reported "no symptoms" on proton pump inhibitor (56% men versus 39% women, p = 0.04), although the histological response was similar between genders (p = 0.4). The proportions of food bolus obstructions and dilations were comparable (all p > 0.4).
This study found very few gender differences. Results suggest that men and women with EoE may receive the same treatment.
none.
not relevant.
嗜酸细胞性食管炎（EoE）的发病率存在性别差异，男性比女性更容易患病。然而，对于 EoE 的大多数其他方面，我们对性别差异的了解还很有限。在这项基于人群的成人 EoE 队列研究中，我们旨在研究性别差异是否存在于以下方面：1）临床表型，2）治疗反应和 3）并发症。
这是一项回顾性、基于登记的丹麦 EoE 队列研究，纳入了 2007 年至 2017 年期间在丹麦北日德兰地区诊断的 236 例成人 EoE 患者（178 例成年男性和 58 例成年女性）。通过医疗登记系统搜索患者记录和病理报告。
在症状、诊断时的宏观或组织学表现方面，未发现表型方面存在统计学或临床意义上的性别差异（所有 p > 0.3）。男性和女性在症状和组织学方面的随访数量相当（所有 p > 0.3）。尽管性别间的组织学反应相似（p = 0.4），但更多的男性报告“无症状”（56%的男性 vs. 39%的女性，p = 0.04），而接受质子泵抑制剂治疗的比例则相当（p > 0.4）。食物团块梗阻和扩张的比例相当（所有 p > 0.4）。
本研究发现性别差异很少。结果表明，患有 EoE 的男性和女性可能接受相同的治疗。
无。
不适用。
