Faiman C P, De Erausquin G A, Baratti C M
Cátedra de Farmacología, Facultad de Farmacia y Biquímica, Universidad de Buenos Aires, Argentina.
Behav Neural Biol. 1987 Nov;48(3):434-9. doi: 10.1016/s0163-1047(87)90996-4.
Lysine vasopressin (0.03 microgram/kg, sc) enhanced retention of a one-trial, step-through inhibitory avoidance task when injected into male Swiss mice immediately post-training, as indicated by retention performance 48 h later. A low dose of the vasopressin antagonist, AAVP (0.01 microgram/kg, sc), did not significantly affect retention, whereas a higher dose (0.03 microgram/kg, sc) impaired retention. Neither lysine vasopressin nor AAVP modified latencies to step-through of mice that had not received a footshock during training. The simultaneous injection of AAVP (0.01 microgram/kg, sc) prevented the enhancement of retention induced by lysine vasopressin. The influence of lysine vasopressin on retention was antagonized by the simultaneous administration of mecamylamine (5 mg/kg, sc) but not by hexamethonium (5 mg/kg, sc), atropine (0.5 mg/kg, sc), or methylatropine (0.5 mg/kg, sc). A modulatory role of vasopressin on the activity of central cholinergic nicotinic mechanisms which participate in memory formation is suggested.
赖氨酸加压素（0.03微克/千克，皮下注射）在训练后立即注射到雄性瑞士小鼠体内时，增强了一次性穿梭抑制性回避任务的记忆保持，48小时后的记忆保持表现表明了这一点。低剂量的加压素拮抗剂AAVP（0.01微克/千克，皮下注射）对记忆保持没有显著影响，而高剂量（0.03微克/千克，皮下注射）则损害了记忆保持。赖氨酸加压素和AAVP都没有改变在训练期间未接受电击的小鼠的穿梭潜伏期。同时注射AAVP（0.01微克/千克，皮下注射）可阻止赖氨酸加压素诱导的记忆保持增强。同时给予美加明（5毫克/千克，皮下注射）可拮抗赖氨酸加压素对记忆保持的影响，但六甲铵（5毫克/千克，皮下注射）、阿托品（0.5毫克/千克，皮下注射）或甲基阿托品（0.5毫克/千克，皮下注射）则不能。提示加压素对参与记忆形成的中枢胆碱能烟碱机制的活性具有调节作用。
