人单核白细胞中反式氧化茋活性谷胱甘肽转移酶与肝脏谷胱甘肽转移酶μ相同。
The trans-stilbene oxide-active glutathione transferase in human mononuclear leucocytes is identical with the hepatic glutathione transferase mu.
作者信息
Seidegård J, Guthenberg C, Pero R W, Mannervik B
机构信息
Department of Molecular Ecogenetics, Wallenberg Laboratory, University of Lund, Sweden.
出版信息
Biochem J. 1987 Sep 15;246(3):783-5. doi: 10.1042/bj2460783.
Abstract
A glutathione transferase from human mononuclear leucocytes with high activity towards trans-stilbene oxide (GT-tSBO) was purified. GT-tSBO is expressed in only about 50% of the individuals studied. As judged from activity measurements, immunological studies and the fact that only those individuals who express glutathione transferase mu have high activity towards trans-stilbene oxide, it is concluded that the hepatic transferase mu is identical with the glutathione transferase (GT-tSBO) in mononuclear leucocytes.
摘要
一种对反式氧化芪具有高活性的人单核白细胞谷胱甘肽转移酶（GT-tSBO）被纯化出来。在所研究的个体中，只有约50%表达GT-tSBO。从活性测量、免疫学研究以及只有那些表达谷胱甘肽转移酶μ的个体对反式氧化芪具有高活性这一事实判断，得出肝脏转移酶μ与单核白细胞中的谷胱甘肽转移酶（GT-tSBO）相同的结论。
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