大鼠血浆中高密度脂蛋白对血小板活化因子的降解作用。乙炔雌二醇给药的影响。
The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration.
作者信息
Pritchard P H
机构信息
Department of Pathology, University of British Columbia, Vancouver, Canada.
出版信息
Biochem J. 1987 Sep 15;246(3):791-4. doi: 10.1042/bj2460791.
Abstract
The degradation of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human plasma is brought about by a specific acetylhydrolase that is associated with low-density lipoprotein. In this study, the presence of a similar activity on high-density lipoprotein (HDL) of rat plasma has been demonstrated which is independent of lecithin-cholesterol acyltransferase (LCAT) activity. Furthermore, PAF acetylhydrolase activity may be decreased by 66% by treatment of rats with 17 alpha-ethynyloestradiol (1 mg/kg body wt.; 5 days). This treatment also decreased HDL cholesterol concentrations by 90%, but did not affect LCAT activity. Thus rat LCAT and PAF acetylhydrolase are associated with different subspecies of HDL.
摘要
人血浆中血小板活化因子（PAF；1-O-烷基-2-乙酰基-sn-甘油-3-磷酸胆碱）的降解是由一种与低密度脂蛋白相关的特异性乙酰水解酶引起的。在本研究中，已证实在大鼠血浆的高密度脂蛋白（HDL）上存在类似活性，且该活性独立于卵磷脂胆固醇酰基转移酶（LCAT）活性。此外，用17α-乙炔雌二醇（1mg/kg体重；5天）处理大鼠可使PAF乙酰水解酶活性降低66%。该处理还使HDL胆固醇浓度降低了90%，但不影响LCAT活性。因此，大鼠LCAT和PAF乙酰水解酶与HDL的不同亚类相关。
相似文献
1
The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration.大鼠血浆中高密度脂蛋白对血小板活化因子的降解作用。乙炔雌二醇给药的影响。
Biochem J. 1987 Sep 15;246(3):791-4. doi: 10.1042/bj2460791.
2
3
4
Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase.卵磷脂胆固醇酰基转移酶对血小板活化因子的水解和转酯作用。
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6035-9. doi: 10.1073/pnas.91.13.6035.
5
Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration.小鼠卵磷脂胆固醇酰基转移酶基因的靶向破坏与血浆对氧磷酶和血小板活化因子乙酰水解酶活性降低有关，但与载脂蛋白J浓度无关。
J Lipid Res. 1999 Jul;40(7):1276-83.
6
Hepatic regulation of platelet-activating factor acetylhydrolase and lecithin:cholesterol acyltransferase biliary and plasma output in rats exposed to bacterial lipopolysaccharide.细菌脂多糖暴露大鼠中肝脏对血小板活化因子乙酰水解酶和卵磷脂胆固醇酰基转移酶胆汁及血浆输出的调节作用
Hepatology. 1999 Jul;30(1):128-36. doi: 10.1002/hep.510300122.
7
8
Human plasma platelet-activating factor acetylhydrolase. Purification and properties.人血浆血小板活化因子乙酰水解酶。纯化及性质
J Biol Chem. 1987 Mar 25;262(9):4223-30.
9
Lipid oxidation in carriers of lecithin:cholesterol acyltransferase gene mutations.卵磷脂胆固醇酰基转移酶基因突变携带者中的脂质氧化。
Arterioscler Thromb Vasc Biol. 2012 Dec;32(12):3066-75. doi: 10.1161/ATVBAHA.112.255711. Epub 2012 Sep 27.
10
Variation in plasma platelet-activating factor degradation and serum lipids after acute myocardial infarction.
Coron Artery Dis. 1993 Feb;4(2):187-93. doi: 10.1097/00019501-199302000-00009.
引用本文的文献
1
Thrombocytes and Platelet-Rich Plasma as Modulators of Reproduction and Fertility.血小板和富含血小板的血浆作为生殖和生育的调节剂。
Int J Mol Sci. 2023 Dec 11;24(24):17336. doi: 10.3390/ijms242417336.
2
Non-targeted Metabolomics Reveals Metabolic Characteristics of Porcine Atretic Follicles.非靶向代谢组学揭示猪闭锁卵泡的代谢特征。
Front Vet Sci. 2021 Jul 26;8:679947. doi: 10.3389/fvets.2021.679947. eCollection 2021.
3
"Platelet-associated regulatory system (PARS)" with particular reference to female reproduction.特别涉及女性生殖的“血小板相关调节系统（PARS）”
J Ovarian Res. 2014 May 16;7:55. doi: 10.1186/1757-2215-7-55. eCollection 2014.
4
Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high density lipoprotein.介导血小板活化因子乙酰水解酶与高密度脂蛋白结合的结构域的鉴定。
J Biol Chem. 2008 Jun 20;283(25):17099-106. doi: 10.1074/jbc.M802394200. Epub 2008 Apr 22.
5
Human platelets release a paf-acether: acetylhydrolase similar to that in plasma.人类血小板释放一种血小板活化因子乙酰水解酶：与血浆中的类似。
Lipids. 1993 Mar;28(3):193-9. doi: 10.1007/BF02536639.
6
Hydrolysis and transesterification of platelet-activating factor by lecithin-cholesterol acyltransferase.卵磷脂胆固醇酰基转移酶对血小板活化因子的水解和转酯作用。
Proc Natl Acad Sci U S A. 1994 Jun 21;91(13):6035-9. doi: 10.1073/pnas.91.13.6035.
7
The hormonal regulation of platelet-activating factor acetylhydrolase activity in plasma.血浆中血小板活化因子乙酰水解酶活性的激素调节
Lipids. 1991 Dec;26(12):1015-20. doi: 10.1007/BF02536494.
本文引用的文献
1
Phosphorus assay in column chromatography.柱色谱法中的磷测定
J Biol Chem. 1959 Mar;234(3):466-8.
2
A simple method for the isolation and purification of total lipides from animal tissues.一种从动物组织中分离和纯化总脂质的简单方法。
J Biol Chem. 1957 May;226(1):497-509.
3
4
Preliminary studies of an acid-labile factor (ALF) in human sera that inactivates platelet-activating factor (PAF).对人血清中一种可使血小板活化因子（PAF）失活的酸不稳定因子（ALF）的初步研究。
Clin Immunol Immunopathol. 1980 Mar;15(3):318-330. doi: 10.1016/0090-1229(80)90044-6.
5
Inactivation of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by a plasma acetylhydrolase: higher activities in hypertensive rats.血浆乙酰水解酶对1-烷基-2-乙酰-sn-甘油-3-磷酸胆碱的失活作用：高血压大鼠中活性更高
Biochem Biophys Res Commun. 1983 Jun 15;113(2):666-71. doi: 10.1016/0006-291x(83)91778-3.
6
Cooperative effects of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (PAF-acether) and exogenous arachidonic acid in stimulation of human blood platelets.
Thromb Res. 1984 Feb 15;33(4):409-18. doi: 10.1016/0049-3848(84)90080-x.
7
Human serum acid-labile factor is an acylhydrolase that inactivates platelet-activating factor.
Fed Proc. 1983 Nov;42(14):3120-2.
8
Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets.兔血小板将1-烷基-2-乙酰基-sn-甘油转化为血小板活化因子及相关磷脂。
Biochem Biophys Res Commun. 1984 Oct 15;124(1):156-63. doi: 10.1016/0006-291x(84)90930-6.
9
Lecithin: cholesterol acyltransferase and the regulation of endogenous cholesterol transport.卵磷脂：胆固醇酰基转移酶与内源性胆固醇转运的调节
Adv Lipid Res. 1983;20:107-94.
Zotero 插件