Cheng Bo, Li Chengpeng, Zhang Bo, Liu Jupen, Lu Zhe, Zhang Ping, Wei Hongqiu, Yu You
School of Mechanical Engineering, North University of China, Taiyuan 030051, China.
National Engineering Research Center for Biomaterials, Sichuan University, Chengdu 610017, China.
ACS Appl Mater Interfaces. 2023 Mar 9. doi: 10.1021/acsami.3c00065.
Hydrogels have demonstrated wide applications in tissue engineering, but it is still challenging to develop strong, customizable, low-friction artificial scaffolds. Here, we report a rapid orthogonal photoreactive 3D-printing (ROP3P) strategy to achieve the design of high-performance hydrogels in tens of minutes. The orthogonal ruthenium chemistry enables the formation of multinetworks in hydrogels via phenol-coupling reaction and traditional radical polymerization. Further Ca-cross-linking treatment greatly improves their mechanical properties (6.4 MPa at a critical strain of 300%) and toughness (10.85 MJ m). The tribological investigation reveals that the high elastic moduli of the as-prepared hydrogels improve their lubrication (∼0.02) and wear-resistance performances. These hydrogels are biocompatible and nontoxic and promote bone marrow mesenchymal stem cell adhesion and propagation. The introduction of 1-hydroxy-3-(acryloylamino)-1,1-propanediylbisphosphonic acid units can greatly enhance their antibacterial property to kill typical and . Moreover, the rapid ROP3P can achieve hydrogel preparation in several seconds and is readily compatible with making artificial meniscus scaffolds. The printed meniscus-like materials are mechanically stable and can maintain their shape under long-term gliding tests. It is anticipated that these high-performance customizable low-friction tough hydrogels and the highly efficient ROP3P strategy could promote further development and practical applications of hydrogels in biomimetic tissue engineering, materials chemistry, bioelectronics, and so on.
水凝胶已在组织工程中展现出广泛应用，但开发坚固、可定制、低摩擦的人工支架仍然具有挑战性。在此，我们报告一种快速正交光反应性3D打印（ROP3P）策略，可在数十分钟内实现高性能水凝胶的设计。正交钌化学通过苯酚偶联反应和传统自由基聚合实现水凝胶中多网络的形成。进一步的钙交联处理极大地改善了它们的机械性能（在300%的临界应变下为6.4兆帕）和韧性（10.85兆焦/立方米）。摩擦学研究表明，所制备水凝胶的高弹性模量改善了其润滑性能（约0.02）和耐磨性能。这些水凝胶具有生物相容性且无毒，可促进骨髓间充质干细胞的黏附和增殖。引入1-羟基-3-（丙烯酰氨基）-1,1-丙二基双膦酸单元可极大增强其抗菌性能，以杀灭典型的[细菌名称未给出]和[细菌名称未给出]。此外，快速ROP3P可在数秒内完成水凝胶制备，并且易于与制作人工半月板支架兼容。打印的半月板样材料机械稳定，在长期滑动测试下能保持其形状。预计这些高性能、可定制、低摩擦的坚韧水凝胶以及高效的ROP3P策略可促进水凝胶在仿生组织工程、材料化学、生物电子学等领域的进一步发展和实际应用。
