Hell Franz, Eißner Annika, Mehrkens Jan H, Bötzel Kai
Department of Neurology, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 Munich, Germany; Graduate School of Systemic Neurosciences, Ludwig-Maximilians-Universität München, Grosshadernerstr. 2, 82152 Martinsried, Germany.
Department of Neurology, Ludwig-Maximilians-Universität München, Marchioninistr. 15, 81377 Munich, Germany.
Clin Neurophysiol. 2023 May;149:42-50. doi: 10.1016/j.clinph.2023.02.166. Epub 2023 Feb 25.
We studied the relationship between oscillatory activity in the subthalamic nucleus (STN) and speech production in order to better understand the functional role of the STN.
We simultaneously recorded subthalamic local field potentials and audio recordings from 5 patients with Parkinson's disease while they performed verbal fluency tasks. We then analyzed the oscillatory signals present in the subthalamic nucleus during these tasks.
We report that normal speech leads to a suppression of subthalamic alpha and beta power. Contrarily, a patient with motor blocks during speech initiation showed a low beta power increase. We also report an increase in error rates in the phonemic non-alternating verbal fluency task during deep brain stimulation (DBS).
We confirm previous findings that intact speech leads to desynchronization in the beta range in the STN. The speech related narrowband beta power increase in a patient with speech problems suggests that exaggerated synchronization in this frequency band is associated with motor blocks during speech initiation. The increased number of errors in verbal fluency tasks during DBS might be caused by an impairment of the response inhibition network caused by stimulation of the STN.
We suggest that the inability to attenuate beta activity during motor processes is associated with motor freezing across motor behaviours such as speech and gait, as previously shown for freezing of gait.
我们研究了丘脑底核（STN）的振荡活动与言语产生之间的关系，以便更好地理解STN的功能作用。
我们同时记录了5例帕金森病患者在执行言语流畅性任务时丘脑底核的局部场电位和音频记录。然后我们分析了这些任务期间丘脑底核中存在的振荡信号。
我们报告正常言语会导致丘脑底核α和β功率的抑制。相反，一名在言语起始时出现运动阻滞的患者显示β功率轻度增加。我们还报告了在深部脑刺激（DBS）期间音素非交替言语流畅性任务中的错误率增加。
我们证实了先前的发现，即完整的言语会导致STN中β频段的去同步化。一名有言语问题的患者中与言语相关的窄带β功率增加表明，该频段中过度的同步化与言语起始时的运动阻滞有关。DBS期间言语流畅性任务中错误数量的增加可能是由于STN刺激导致反应抑制网络受损所致。
我们认为，在运动过程中无法减弱β活动与言语和步态等运动行为中的运动冻结有关，正如先前在步态冻结中所显示的那样。
