逃逸载具：真菌HscA引导人类吞噬体p11进入逃逸路径。
Getaway car: Fungal HscA steers human phagosomal p11 into an escape route.
作者信息
Camacho Emma, Coelho Carolina
机构信息
W. Harry Feinstone Department of Molecular Microbiology and Immunology, The Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.
MRC Centre for Medical Mycology at University of Exeter, Exeter, EX4 4QD Devon, UK.
出版信息
Cell Host Microbe. 2023 Mar 8;31(3):324-327. doi: 10.1016/j.chom.2023.02.006.
In this issue of Cell Host & Microbe, Jia and colleagues discover how the human p11 (s100A10)-Anxa2 heterodimer drives sorting of microbial phagosomes into recycling versus degradative pathways. In a remarkable evolutionary arms race, the Aspergillus fumigatus protein HscA latches to p11 to steer its phagosome away from fungal killing.
在本期《细胞宿主与微生物》中，贾及其同事发现了人类p11（S100A10）-膜联蛋白A2异二聚体如何驱动微生物吞噬体进入循环与降解途径的分选过程。在一场引人注目的进化军备竞赛中，烟曲霉蛋白HscA附着于p11，以使吞噬体避开对真菌的杀伤作用。
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