Gilmour Gabriela S, Lidstone Sarah C
Edmond J. Safra Program in Parkinson's Disease and the Morton and Gloria Shulman Movement Disorders Clinic, University Health Network, Toronto, Ontario, Canada.
Integrated Movement Disorders Program, Toronto Rehabilitation Institute, University Health Network, Toronto, Ontario, Canada.
Semin Neurol. 2023 Feb;43(1):106-122. doi: 10.1055/s-0043-1763505. Epub 2023 Mar 9.
Functional movement disorder (FMD) is a complex neuropsychiatric syndrome, encompassing abnormal movements and weakness, and is a common cause of potentially disabling neurological symptoms. It is vital to recognize that FMD is a syndrome, with nonmotor manifestations negatively affecting a patient's quality of life. This review highlights a diagnostic algorithm, where a history suggestive of FMD is combined with the presence of positive signs on examination and appropriate investigations to make the diagnosis. Positive signs indicate internal inconsistency such as variability and distractibility, and clinical findings that are incongruent with other known neurological disease. Importantly, the clinical assessment acts as the first opportunity to allow patients to understand FMD as the cause for their symptoms. Accurate and early diagnosis of FMD is necessary given that it is a treatable and potentially reversible cause of disability, with significant risk of iatrogenic harm associated with misdiagnosis.
功能性运动障碍(FMD)是一种复杂的神经精神综合征,包括异常运动和无力,是潜在致残性神经症状的常见原因。必须认识到,FMD是一种综合征,其非运动表现会对患者的生活质量产生负面影响。本综述重点介绍了一种诊断算法,即提示FMD的病史与检查时的阳性体征及适当的检查相结合以做出诊断。阳性体征表明存在内部不一致性,如变异性和易分散性,以及与其他已知神经疾病不符的临床发现。重要的是,临床评估是让患者了解FMD是其症状原因的首个契机。鉴于FMD是一种可治疗且可能可逆的致残原因,且误诊会带来重大医源性伤害风险,因此对FMD进行准确、早期诊断很有必要。