N-乙酰血清素及其衍生物的神经保护作用。
Neuroprotective Effects of N-acetylserotonin and Its Derivative.
机构信息
Orthopedics Department, the Second Hospital of Lanzhou University, Lanzhou, China; Orthopedics Department, the Second Clinical Medical College of Lanzhou University, Lanzhou, China.
Orthopedics Department, the Second Hospital of Lanzhou University, Lanzhou, China.
出版信息
Neuroscience. 2023 May 1;517:18-25. doi: 10.1016/j.neuroscience.2023.02.017. Epub 2023 Mar 8.
N-acetylserotonin (NAS) is a chemical intermediate in melatonin biosynthesis. NAS and its derivative N-(2-(5-hydroxy-1H-indol-3-yl) ethyl)-2-oxopiperidine-3-carboxamide (HIOC) are potential therapeutic agents for traumatic brain injury, autoimmune encephalomyelitis, hypoxic-ischemic encephalopathy, and other diseases. Evidence shows that NAS and its derivative HIOC have neuroprotective properties, and can exert neuroprotective effects by inhibiting oxidative stress, anti-apoptosis, regulating autophagy dysfunction, and anti-inflammatory. In this review, we discussed the neuroprotective effects and related mechanisms of NAS and its derivative HIOC to provide a reference for follow-up research and applications.
N-乙酰血清素（NAS）是褪黑素生物合成中的一种化学中间体。NAS 及其衍生物 N-(2-(5-羟基-1H-吲哚-3-基)乙基)-2-氧代哌啶-3-甲酰胺（HIOC）是创伤性脑损伤、自身免疫性脑脊髓炎、缺氧缺血性脑病和其他疾病的潜在治疗药物。有证据表明，NAS 及其衍生物 HIOC 具有神经保护特性，通过抑制氧化应激、抗细胞凋亡、调节自噬功能障碍和抗炎作用来发挥神经保护作用。在本文中，我们讨论了 NAS 及其衍生物 HIOC 的神经保护作用及其相关机制，为后续的研究和应用提供参考。
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