Skjeflo Espen W, Evensen Line H, Jensen Søren B, Latysheva Nadezhda, Michelsen Annika, Ueland Thor, Brækkan Sigrid K, Hindberg Kristian, Snir Omri, Mollnes Tom Eirik, Hansen John-Bjarne
K.G. Jebsen - Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø - The Arctic University of Norway, Tromsø, Norway; Research Laboratory, Nordland Hospital, Bodø, Norway.
K.G. Jebsen - Thrombosis Research and Expertise Center (TREC), Department of Clinical Medicine, University of Tromsø - The Arctic University of Norway, Tromsø, Norway.
Clin Immunol. 2023 Apr;249:109278. doi: 10.1016/j.clim.2023.109278. Epub 2023 Mar 7.
The complement system appears to be involved in the pathogenesis of venous thromboembolism (VTE). We investigated the association of complement factors (CF) B, D, and the alternative pathway convertase, C3bBbP, measured at inclusion, with the risk of future VTE in a nested case-control study; 380 VTE patients and 804 age- and sex-matched controls derived from the Tromsø study. Odds ratios (ORs) with 95% confidence intervals (95% CI) for VTE across tertiles of CF concentrations were estimated using logistic regression. There was no association between CFB or CFD and risk of future VTE. Higher levels of C3bBbP gave an increased risk of provoked VTE; subjects in Q4 had a 1.68-fold higher OR compared with Q1 in the age-, sex- and BMI-adjusted model (OR 1.68; 95% CI 1.08-2.64). There was no increased risk of future VTE in individuals with higher levels of complement factors B or D of the alternative pathway. Increased levels of the alternative pathway activation product, C3bBbP, showed an association with future risk of provoked VTE.
补体系统似乎参与了静脉血栓栓塞症（VTE）的发病机制。在一项巢式病例对照研究中，我们调查了纳入研究时所测量的补体因子（CF）B、D以及替代途径转化酶C3bBbP与未来发生VTE风险之间的关联；研究对象来自特罗姆瑟研究中的380例VTE患者以及804例年龄和性别匹配的对照。使用逻辑回归估计CF浓度三分位数组中VTE的比值比（OR）及95%置信区间（95%CI）。CFB或CFD与未来发生VTE的风险之间无关联。较高水平的C3bBbP会增加诱发VTE的风险；在年龄、性别和体重指数调整模型中，四分位数4中的受试者与四分位数1中的受试者相比，OR高出1.68倍（OR 1.68；95%CI 1.08 - 2.64）。替代途径中补体因子B或D水平较高的个体，未来发生VTE的风险并未增加。替代途径激活产物C3bBbP水平升高与未来诱发VTE的风险相关。
