Department of Neurosurgery, Tianjin Hospital, Tianjin, P. R. China.
School of Life Science, Shandong University of Technology, Zibo, P. R. China.
Luminescence. 2023 Apr;38(4):497-504. doi: 10.1002/bio.4476. Epub 2023 Mar 25.
An organic chemical with fluorescence quenching properties [aggregation-caused quenching (ACQ)] may often be transformed by adding functional groups that cause aggregation-induced emission (AIE) to its molecular scaffold. Such structural change techniques, however, sometimes require challenging chemical reactions. SF136 is a type of chalcone, and it is an typical ACQ organic compound. In this study, cationic surfactants like hexadecyltrimethylammonium bromide (CTAB) and polyethyleneimine (PEI) were used to convert the ACQ compound SF136 into an AIE compound without adding any AIE structure units. In comparison to SF136, the SF136-CTAB NPS system not only demonstrated improved bacterial fluorescence imaging capabilities, but also increased photodynamic antibacterial activity, which is connected to its improved targeting and reactive oxygen species (ROS) production abilities. It is a promising theranostic substance against bacteria owing to these enhanced qualities. Other ACQ fluorescent compounds may also benefit from using this approach, broadening the scope of their potential applications.
一种具有荧光猝灭特性（聚集诱导猝灭，ACQ）的有机化合物[1]，通常可以通过在其分子骨架上添加引起聚集诱导发光（AIE）的官能团来进行转化。然而，这种结构变化技术有时需要具有挑战性的化学反应[2]。SF136 是一种查尔酮，它是一种典型的 ACQ 有机化合物。在这项研究中，十六烷基三甲基溴化铵（CTAB）和聚乙烯亚胺（PEI）等阳离子表面活性剂被用于将 ACQ 化合物 SF136 转化为无需添加任何 AIE 结构单元的 AIE 化合物[3]。与 SF136 相比，SF136-CTAB NPS 体系不仅表现出改善的细菌荧光成像能力，而且还提高了光动力抗菌活性，这与其改善的靶向和活性氧（ROS）产生能力有关[4]。由于这些增强的特性，它是一种有前途的针对细菌的治疗药物。其他 ACQ 荧光化合物也可能受益于使用这种方法，从而拓宽了它们的潜在应用范围[5]。
