黄嘌呤类拮抗剂 PACPX（1,3 - 二丙基 - 8(2 - 氨基 - 4 - 氯)苯基黄嘌呤）和 8 - PT（8 - 苯基茶碱）在大鼠脑组织中腺苷 A1 和 A2 受体上的拮抗作用的生化特性 - Suppr

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超能文献

Biochemical characterization of the antagonist actions of the xanthines, PACPX (1,3-dipropyl-8(2-amino-4-chloro)phenylxanthine) and 8-PT (8-phenyltheophylline) at adenosine A1 and A2 receptors in rat brain tissue.

作者信息

Williams M, Jarvis M F, Sills M A, Ferkany J W, Braunwalder A

机构信息

Research Department, CIBA-GEIGY Corp. Summit NJ 07901.

出版信息

Biochem Pharmacol. 1987 Nov 15;36(22):4024-7. doi: 10.1016/0006-2952(87)90476-x.

DOI:10.1016/0006-2952(87)90476-x

PMID:3689436

Abstract

摘要

相似文献

Biochemical characterization of the antagonist actions of the xanthines, PACPX (1,3-dipropyl-8(2-amino-4-chloro)phenylxanthine) and 8-PT (8-phenyltheophylline) at adenosine A1 and A2 receptors in rat brain tissue.黄嘌呤类拮抗剂 PACPX（1,3 - 二丙基 - 8(2 - 氨基 - 4 - 氯)苯基黄嘌呤）和 8 - PT（8 - 苯基茶碱）在大鼠脑组织中腺苷 A1 和 A2 受体上的拮抗作用的生化特性

Biochem Pharmacol. 1987 Nov 15;36(22):4024-7. doi: 10.1016/0006-2952(87)90476-x.

Xanthine derivatives as antagonists at A1 and A2 adenosine receptors.

Naunyn Schmiedebergs Arch Pharmacol. 1985 Sep;330(3):212-21. doi: 10.1007/BF00572436.

125I-labeled 8-phenylxanthine derivatives: antagonist radioligands for adenosine A1 receptors.125I标记的8-苯基黄嘌呤衍生物：腺苷A1受体的拮抗剂放射性配体

J Med Chem. 1988 Apr;31(4):745-51. doi: 10.1021/jm00399a010.

[3H]CGS 21680, a selective A2 adenosine receptor agonist directly labels A2 receptors in rat brain.[3H]CGS 21680，一种选择性A2腺苷受体激动剂，可直接标记大鼠脑中的A2受体。

J Pharmacol Exp Ther. 1989 Dec;251(3):888-93.

Evidence that adenosine receptors in the dog left atrium are not of the typical A1 or A2 adenosine receptor subtypes.有证据表明，犬左心房中的腺苷受体并非典型的A1或A2腺苷受体亚型。

Eur J Pharmacol. 1992 Apr 22;214(2-3):199-205. doi: 10.1016/0014-2999(92)90119-o.

PACPX--a substituted xanthine--antagonizes both the A1 and A2 subclasses of the P1-purinoceptor: antagonism of the A2 subclass is competitive but antagonism of the A1 subclass is not.PACPX（一种取代黄嘌呤）可拮抗P1嘌呤受体的A1和A2两个亚类：对A2亚类的拮抗作用是竞争性的，但对A1亚类的拮抗作用并非如此。

Br J Pharmacol. 1985 May;85(1):291-6. doi: 10.1111/j.1476-5381.1985.tb08859.x.

Apparent affinity of some 8-phenyl-substituted xanthines at adenosine receptors in guinea-pig aorta and atria.某些8-苯基取代黄嘌呤对豚鼠主动脉和心房中腺苷受体的表观亲和力。

Br J Pharmacol. 1987 Sep;92(1):69-75. doi: 10.1111/j.1476-5381.1987.tb11297.x.

Identification and functional characterization of A1 and A2 adenosine receptors in the rat vas deferens: a comparison with A1 receptors in guinea pig left atrium and A2 receptors in guinea pig aorta.大鼠输精管中A1和A2腺苷受体的鉴定及功能特性：与豚鼠左心房中的A1受体和豚鼠主动脉中的A2受体的比较。

J Pharmacol Exp Ther. 1994 Jun;269(3):1228-35.

Selective activity of bamifylline on adenosine A1-receptors in rat brain.巴米茶碱对大鼠脑内腺苷 A1 受体的选择性作用。

Pharmacol Res Commun. 1987 Aug;19(8):537-45. doi: 10.1016/0031-6989(87)90091-9.

Antagonism of adenosine-induced relaxation by methylxanthines in coronary artery.甲基黄嘌呤对腺苷诱导的冠状动脉舒张作用的拮抗作用。

Arch Int Pharmacodyn Ther. 1988 Sep-Oct;295:174-80.

引用本文的文献

Characterization of the adenosine receptors of the rat superior cervical ganglion.大鼠颈上神经节腺苷受体的特性研究

Br J Pharmacol. 1993 Oct;110(2):854-60. doi: 10.1111/j.1476-5381.1993.tb13891.x.

1,3,8- and 1,3,7-substituted xanthines: relative potency as adenosine receptor antagonists at the frog neuromuscular junction.1,3,8-和1,3,7-取代的黄嘌呤：在青蛙神经肌肉接头处作为腺苷受体拮抗剂的相对效力

Br J Pharmacol. 1989 Jan;96(1):211-9. doi: 10.1111/j.1476-5381.1989.tb11802.x.

Analysis of agonist-antagonist interactions at A1 adenosine receptors.A1 腺苷受体激动剂-拮抗剂相互作用分析

Mol Pharmacol. 1990 Jul;38(1):72-83.

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