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产后皮质类固醇治疗作为严重联合免疫缺陷新生儿筛查中假阳性的危险因素。

Postnatal corticosteroid treatment as a risk factor for false positivity in severe combined immunodeficiency newborn screening.

机构信息

Department of Pediatrics, Sin-Lau Christian Hospital, Tainan, Taiwan; Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan.

Department of Pediatrics, National Cheng-Kung University Hospital, Tainan, Taiwan; Department of Pediatrics, Kuo General Hospital, Taiwan.

出版信息

J Microbiol Immunol Infect. 2023 Aug;56(4):871-874. doi: 10.1016/j.jmii.2023.02.001. Epub 2023 Feb 28.

DOI:10.1016/j.jmii.2023.02.001
PMID:36894477
Abstract

From 2011, 37 children were referred to a hospital due to low levels of T cell receptor excision circles (TRECs) from newborn screening. Among them, three children were immunologically characterized and followed up to show that postnatal corticosteroid usage may be among the causes of false positivity in TRECs screening.

摘要

自 2011 年以来，共有 37 名儿童因新生儿筛查中 T 细胞受体切除环（TRECs）水平低而被转至医院。其中，有 3 名儿童进行了免疫特征分析并接受了随访，结果表明，皮质类固醇的产后使用可能是 TRECs 筛查假阳性的原因之一。

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