Department of General Surgery, Baoding First Central Hospital, Baoding, China.
School of Clinical Medicine, Hebei University, Baoding, China.
Nutr Cancer. 2023;75(4):1233-1242. doi: 10.1080/01635581.2023.2186267. Epub 2023 Mar 9.
Previous studies have investigated the prognostic value of the advanced lung cancer inflammation index (ALI) in gastrointestinal (GI) cancers; however, the results are controversial. This meta-analysis aimed to evaluate the prognostic and clinicopathological role of ALI in patients with GI cancers. A systematic search of electronic databases was conducted to evaluate the prognostic and clinicopathological value of ALI in GI cancers. Nine studies comprising 3,750 patients were included in this meta-analysis. The pooled results showed that a low ALI was significantly associated with worse overall survival (OS, hazard ratio [HR] = 1.95, 95% confidence interval [CI] = 1.53-2.47, < 0.001, = 63.9%) and disease-free survival/relapse-free survival (DFS/RFS, HR = 1.49, 95% CI = 1.28-1.73, < 0.001, = 0%) in patients with GI cancers. In addition, decreased ALI correlated with the depth of tumor invasion and presence of distant metastasis and tended to be associated with male sex, high carcinoembryonic antigen levels, lymph node metastasis, and right-sided colon cancer. Low ALI was associated with adverse OS and DFS/RFS in patients with GI cancer. In addition, decreased ALI also correlated with clinicopathological factors, indicating higher stage of the malignancy.
先前的研究已经探讨了晚期肺癌炎症指数（ALI）在胃肠道（GI）癌症中的预后价值；然而，结果存在争议。本荟萃分析旨在评估 ALI 在 GI 癌症患者中的预后和临床病理作用。系统地检索了电子数据库，以评估 ALI 在 GI 癌症中的预后和临床病理价值。这项荟萃分析共纳入了 9 项研究，包括 3750 名患者。汇总结果表明，低 ALI 与 GI 癌症患者的总生存期（OS，风险比[HR] = 1.95，95%置信区间[CI] = 1.53-2.47， < 0.001， = 63.9%）和无病生存/无复发生存（DFS/RFS，HR = 1.49，95% CI = 1.28-1.73， < 0.001， = 0%）显著相关。此外，ALI 降低与肿瘤侵袭深度、远处转移有关，且倾向于与男性、高癌胚抗原水平、淋巴结转移和右半结肠癌相关。低 ALI 与 GI 癌症患者的 OS 和 DFS/RFS 不良相关。此外，ALI 降低也与临床病理因素相关，表明恶性程度更高。
