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Editorial: Rho family GTPases and their effectors in neuronal survival and neurodegeneration.

作者信息

Linseman Daniel A, Lu Qun

机构信息

Department of Biological Sciences, Knoebel Institute for Healthy Aging, University of Denver, Denver, CO, United States.

The Harriet and John Wooten Laboratory for Alzheimer's and Neurodegenerative Diseases Research, Department of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC, United States.

出版信息

Front Cell Neurosci. 2023 Feb 21;17:1161072. doi: 10.3389/fncel.2023.1161072. eCollection 2023.

DOI:10.3389/fncel.2023.1161072
PMID:36896267
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9989285/
Abstract
摘要

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Mol Brain. 2021 Jul 27;14(1):121. doi: 10.1186/s13041-021-00833-3.
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Pharmacologic inhibition of LIMK1 provides dendritic spine resilience against β-amyloid.抑制 LIMK1 的药理作用可增强树突棘对β-淀粉样蛋白的抵抗力。
Sci Signal. 2019 Jun 25;12(587):eaaw9318. doi: 10.1126/scisignal.aaw9318.
3
C9orf72, a protein associated with amyotrophic lateral sclerosis (ALS) is a guanine nucleotide exchange factor.C9orf72是一种与肌萎缩侧索硬化症（ALS）相关的蛋白质，它是一种鸟嘌呤核苷酸交换因子。
PeerJ. 2018 Oct 17;6:e5815. doi: 10.7717/peerj.5815. eCollection 2018.
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Regulation of RhoA activity by the cellular prion protein.细胞朊蛋白对RhoA活性的调控。
Cell Death Dis. 2017 Mar 16;8(3):e2668. doi: 10.1038/cddis.2017.37.
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δ-Catenin Regulates Spine Architecture via Cadherin and PDZ-dependent Interactions.δ-连环蛋白通过钙黏蛋白和PDZ依赖性相互作用调节脊柱结构。
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Cofilin rod formation in neurons impairs neuronal structure and function.神经元中丝切蛋白杆状结构的形成会损害神经元的结构和功能。
CNS Neurol Disord Drug Targets. 2015;14(4):554-60. doi: 10.2174/1871527314666150225144052.
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PLoS One. 2012;7(9):e43728. doi: 10.1371/journal.pone.0043728. Epub 2012 Sep 11.
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Mapping cofilin-actin rods in stressed hippocampal slices and the role of cdc42 in amyloid-beta-induced rods.在应激海马切片中映射丝切蛋白-肌动蛋白棒和 cdc42 在淀粉样β诱导的棒中的作用。
J Alzheimers Dis. 2009;18(1):35-50. doi: 10.3233/JAD-2009-1122.
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