Coleman R E, Rubens R D
Imperial Cancer Research Fund Clinical Oncology Unit, Guy's Hospital, London, UK.
Br J Cancer. 1987 Oct;56(4):465-9. doi: 10.1038/bjc.1987.225.
The effect of a single dose of APD on hypercalcaemia has been studied in advanced breast cancer. Twenty-five patients were rehydrated intravenously for 48 h. Twenty-three remained hypercalcaemic and received 5-15 mg APD as a 2 h infusion. Eighteen patients achieved normocalcaemia, 15 after a dose of less than or equal to 15 mg. One patient died within 24 h from rapidly advancing disease and 4 remained hypercalcaemic. Urinary calcium excretion increased during rehydration as glomerular function improved and tubular reabsorption of calcium fell. After APD, calcium excretion fell to normal in 22/24 patients reflecting inhibition of bone resorption. Hydroxyproline excretion remained high. The effect of a single dose of APD on hypercalcaemia lasted a median of 11 days (range 7-17). Transient fever occurred in 2 patients, but there were no other side effects. The possibility of long-term control of osteolysis using a 2 weekly schedule of APD administration is now being studied.
已在晚期乳腺癌患者中研究了单剂量阿帕替尼（APD）对高钙血症的影响。25例患者接受了48小时的静脉补液。23例患者仍存在高钙血症，接受了5 - 15毫克阿帕替尼，静脉输注2小时。18例患者血钙恢复正常，其中15例在接受剂量小于或等于15毫克后恢复正常。1例患者在24小时内死于疾病快速进展，4例患者仍存在高钙血症。补液期间，随着肾小球功能改善和肾小管对钙的重吸收下降，尿钙排泄增加。使用阿帕替尼后，24例患者中有22例的钙排泄降至正常，这反映了骨吸收受到抑制。羟脯氨酸排泄仍处于较高水平。单剂量阿帕替尼对高钙血症的影响持续时间中位数为11天（范围7 - 17天）。2例患者出现短暂发热，但无其他副作用。目前正在研究采用每两周一次的阿帕替尼给药方案长期控制骨溶解的可能性。
