Future Industries Institute, University of South Australia, Mawson Lakes Campus, Mawson Lakes, South Australia 5095, Australia.
UniSA STEM, University of South Australia, Mawson Lakes Campus, Mawson Lakes, South Australia 5095, Australia.
ACS Sens. 2023 Mar 24;8(3):974-993. doi: 10.1021/acssensors.2c02579. Epub 2023 Mar 10.
Low temperature plasma technology is proving to be at the frontier of emerging medical technologies with real potential to overcome escalating healthcare challenges including antimicrobial and anticancer resistance. However, significant improvements in efficacy, safety, and reproducibility of plasma treatments need to be addressed to realize the full clinical potential of the technology. To improve plasma treatments recent research has focused on integrating automated feedback control systems into medical plasma technologies to maintain optimal performance and safety. However, more advanced diagnostic systems are still needed to provide data into feedback control systems with sufficient levels of sensitivity, accuracy, and reproducibility. These diagnostic systems need to be compatible with the biological target and to also not perturb the plasma treatment. This paper reviews the state-of-the-art electronic and optical sensors that might be suitable to address this unmet technological need, and the steps needed to integrate these sensors into autonomous plasma systems. Realizing this technological gap could facilitate the development of next-generation medical plasma technologies with strong potential to yield superior healthcare outcomes.
低温等离子体技术正处于新兴医疗技术的前沿，具有克服不断升级的医疗保健挑战（包括抗菌和抗癌耐药性）的真正潜力。然而，为了实现该技术的全部临床潜力，需要在疗效、安全性和重现性方面取得重大改进。为了改进等离子体处理，最近的研究集中在将自动化反馈控制系统集成到医疗等离子体技术中，以保持最佳性能和安全性。然而，仍需要更先进的诊断系统，为反馈控制系统提供具有足够灵敏度、准确性和重现性的数据。这些诊断系统需要与生物靶标兼容，并且不会干扰等离子体处理。本文回顾了可能适合解决这一未满足技术需求的电子和光学传感器，并介绍了将这些传感器集成到自主等离子体系统中所需的步骤。实现这一技术差距可以促进下一代医疗等离子体技术的发展，这些技术具有产生卓越医疗效果的巨大潜力。
