Ma Xiaowei, Zhao Jiazheng, Feng Helin
Department of Orthopedics, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 17 Nanli, Panjiayuan, Chaoyang District, Beijing, 100021, People's Republic of China.
Department of Orthopedics, The Fourth Hospital of Hebei Medical University, 12 Health Road, Hebei Province, Shijiazhuang, 050011, People's Republic of China.
Discov Oncol. 2023 Mar 10;14(1):31. doi: 10.1007/s12672-023-00637-y.
Osteosarcoma (OS) is the most common primary solid malignant tumour of bone, with rapid progression and a very poor prognosis. Iron is an essential nutrient that makes it an important player in cellular activities due to its inherent ability to exchange electrons, and its metabolic abnormalities are associated with a variety of diseases. The body tightly regulates iron content at the systemic and cellular levels through various mechanisms to prevent iron deficiency and overload from damaging the body. OS cells regulate various mechanisms to increase the intracellular iron concentration to accelerate proliferation, and some studies have revealed the hidden link between iron metabolism and the occurrence and development of OS. This article briefly describes the process of normal iron metabolism, and focuses on the research progress of abnormal iron metabolism in OS from the systemic and cellular levels.
骨肉瘤（OS）是最常见的原发性骨实体恶性肿瘤，进展迅速且预后极差。铁是一种必需营养素，因其具有电子交换的内在能力，使其在细胞活动中发挥重要作用，其代谢异常与多种疾病相关。机体通过多种机制在全身和细胞水平严格调节铁含量，以防止缺铁和铁过载损害身体。OS细胞通过调节多种机制来提高细胞内铁浓度以加速增殖，一些研究揭示了铁代谢与OS发生发展之间的潜在联系。本文简要介绍正常铁代谢过程，并从全身和细胞水平重点阐述OS中铁代谢异常的研究进展。
