Department of Chemistry, Indian Institute of Technology Jammu, NH-44, PO Nagrota, Jagti, Jammu and Kashmir 181221, India.
Org Lett. 2023 Mar 24;25(11):1889-1894. doi: 10.1021/acs.orglett.3c00404. Epub 2023 Mar 10.
Alkynyl hydrazones are synthesized conveniently from 2-oxo-3-butynoates and hydrazine by suppressing the susceptible formation of pyrazoles. The resultant hydrazones are transformed into alkynyl diazoacetates under metal-free and mild oxidative conditions in excellent yields. Further, the alkynyl cyclopropane and propargyl silane carboxylates are synthesized in good yields by developing an unprecedented copper-catalyzed alkynyl carbene transfer reaction.
炔基腙很方便地由 2-氧代-3-丁炔酸酯和肼合成，抑制了吡唑的生成。所得腙在无金属和温和氧化条件下转化为高产率的炔基重氮乙酸酯。此外，通过开发一种前所未有的铜催化炔基卡宾转移反应，炔基环丙烷和炔丙基硅烷羧酸酯也以良好的收率合成。
