Gupta Sandip Kumar, Panda Niranjan
Department of Chemistry, National Institute of Technology, Rourkela, Odisha 769008, India.
J Org Chem. 2023 Apr 7;88(7):4254-4263. doi: 10.1021/acs.joc.2c02815. Epub 2023 Mar 10.
A Pd(II)-catalyzed dehydrogenative remote C4-H coupling of indoles with unfunctionalized arenes at room temperature was reported. The weak chelating trifluoroacetyl group at the C3-position served as a directing group for the remote C4-H activation. Arenes with a wide range of substituents were employed as the coupling partner in the dehydrogenative cross-coupling reaction.
报道了一种钯（II）催化的吲哚与未官能化芳烃在室温下的远程C4-H脱氢偶联反应。C3位的弱螯合三氟乙酰基作为远程C4-H活化的导向基团。多种取代基的芳烃被用作脱氢交叉偶联反应中的偶联伙伴。
