Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 11, 119228 Singapore.
Infectious Diseases Translational Research Programme, Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, 1E Kent Ridge Road, NUHS Tower Block, Level 11, 119228 Singapore; Division of Infectious Diseases, Department of Medicine, National University Hospital, National University Health System, 1E Kent Ridge Road, NUHS Tower Block, Level 10, 119228 Singapore; Institute for Health Innovation & Technology (iHealthtech), National University of Singapore (NUS), MD6, 14 Medical Drive, #14-01 117599 Singapore.
Int J Infect Dis. 2023 May;130 Suppl 1:S30-S33. doi: 10.1016/j.ijid.2023.02.009. Epub 2023 Mar 8.
The COVID-19 pandemic has significantly disrupted global tuberculosis (TB) control efforts. The mobilization of healthcare resources and personnel to combat the pandemic, and the nationwide lockdown measures resulted in an accumulation of a large number of undiagnosed TB cases. Exacerbating the situation, recent meta-analyses showed that COVID-19-induced diabetes mellitus (DM) is on the increase. DM is an established risk factor for TB disease and worsens outcomes. Patients with concurrent DM and TB had more lung cavitary lesions, and are more likely to fail TB treatment and suffer disease relapse. This may pose a significant challenge to TB control in low- and middle-income countries where a high TB burden is found. There is a need to step up the efforts to end the TB epidemic, which include increased screening for DM among patients with TB, optimizing glycemic control among patients with TB-DM, and intensifying TB-DM research to improve treatment outcomes for patients with TB-DM.
新冠疫情大流行严重扰乱了全球结核病（TB）防控工作。为应对疫情而调动医疗资源和人员，以及全国性的封锁措施导致大量未确诊的结核病病例积压。更糟糕的是，最近的荟萃分析显示，新冠疫情引起的糖尿病（DM）呈上升趋势。DM 是结核病发病的既定危险因素，会使病情恶化。患有 DM 和结核病的患者肺部空洞病变更多，更有可能治疗失败和疾病复发。这可能对结核病负担较高的中低收入国家的结核病防控工作构成重大挑战。因此，需要加紧努力终结结核病疫情，包括加强对结核病患者的 DM 筛查，优化结核病-DM 患者的血糖控制，并加强结核病-DM 研究，以改善结核病-DM 患者的治疗效果。
