Iarygin K N, Sukhikh G T, Vinogradov V A, Kryzhanovskiĭ G N
Biull Eksp Biol Med. 1987 Dec;104(12):700-3.
Stereoselective, saturable, reversible and temperature-dependent binding of ligand of sigma opioid receptors (+)-3H-SKF 10047 to mouse splenocytes has been demonstrated. The estimated Kd value of this interaction (20-100 nM) was similar to that of (+)-3H-SKF 10047-sigma receptor complex. The binding capacity was 100 molecules per cell. A comparatively low affinity, non-stereoselective and temperature-independent binding of (+)-3H-SKF 10047 to mouse splenocytes has also been found.
已证实西格玛阿片受体配体（+）-3H-SKF 10047与小鼠脾细胞存在立体选择性、可饱和、可逆且依赖温度的结合。这种相互作用的估计解离常数（Kd）值（20 - 100 nM）与（+）-3H-SKF 10047-西格玛受体复合物的Kd值相似。结合能力为每个细胞100个分子。还发现（+）-3H-SKF 10047与小鼠脾细胞存在亲和力相对较低、非立体选择性且不依赖温度的结合。
