Litvinov R I, Izmaĭlov S G, Zinkevich O D, Kochev O S, Ermolin G A
Biull Eksp Biol Med. 1987 Dec;104(12):727-30.
Fibronectin (FN) solution purified from human blood plasma significantly increased the breaking strength of skin wounds in rats, when applied locally and/or intravenously. The best effect (more than 2-fold) was revealed after combined local and i. v. application of FN. Maximum stimulating activity was observed on the 3rd postoperative day, directly indicating the importance of FN for the early phases of wound healing. The data suggest the possibility of using FN preparations for the stimulation of tissue repair processes.
从人血浆中纯化得到的纤连蛋白（FN）溶液，局部和/或静脉应用时可显著提高大鼠皮肤伤口的断裂强度。局部和静脉联合应用FN后效果最佳（提高超过2倍）。术后第3天观察到最大刺激活性，直接表明FN在伤口愈合早期阶段的重要性。这些数据表明使用FN制剂刺激组织修复过程具有可能性。
