Frolov V A, Mall G, Rieger P, Derks Kh, Antoni Z
Biull Eksp Biol Med. 1987 Dec;104(12):739-41.
Intensive synthesis of collagen-like substance was revealed in the rabbit myocardium during experimental diphtheria intoxication. It was more marked in the right ventricle 24 hours after the injection of diphtheria toxin. Since similar changes (the substance was mainly formed around blood vessels) have been observed in other cases of toxic myocardial alterations (i.e. ethanol intoxication, injection of pharmacological agents, etc.), it can be assumed that it is a standard protective reaction of the altered heart to the penetration of toxic agents from the blood into the myocardial tissue.
实验性白喉中毒时,兔心肌中出现了胶原样物质的大量合成。注射白喉毒素24小时后,右心室的这种现象更为明显。由于在其他中毒性心肌病变(如乙醇中毒、注射药理制剂等)中也观察到了类似变化(该物质主要在血管周围形成),可以推测这是心脏发生改变后对血液中有毒物质侵入心肌组织的一种标准保护性反应。