Zapata Ana, Fernández-Parra Rocio
Hospital Veterinario de Referencia UCV, Departamento de Medicina y Cirugía Animal, Facultad de Veterinaria y Ciencias Experimentales, Universidad Católica de Valencia San Vicente Mártir, 46018 Valencia, Spain.
Escuela de Doctorado, Programa de Doctorado en Ciencias de la Vida y del Medio Natural, Universidad Católica de Valencia San Vicente Mártir, 46002 Valencia, Spain.
Animals (Basel). 2023 Feb 27;13(5):870. doi: 10.3390/ani13050870.
In the multimodal management of osteoarthritis (OA) in recent decades, the use of feed supplements to maintain joint cartilage has been advocated. The aim of this scoping review is to present the results found in the veterinary literature on the use of undenatured type II collagen and in dogs, specifically its use in dogs with clinical signs of OA, healthy dogs after intense exercise or dogs with diseases that predispose the individual to OA. For this purpose, a literature review was carried out using the electronic databases PubMed, Web of Science and Google Scholar, from which a total of 26 records were included in this review: fourteen evaluating undenatured type II collagen, ten evaluating and two evaluating the combination of undenatured type II collagen and . The review of the records showed that undenatured type II collagen decreases the clinical signs associated with OA, improving the general clinical state with a reduction in the degree of lameness and increase in physical activity or mobility. Evaluating the response to supplementation with alone is complicated due to the limited publication of studies and variations in the purity and compositions of the products used, but in general terms, its combination with other feed supplements produces benefits by relieving pain and reducing the clinical signs of OA in dogs. The combination of both in the same product provides results similar to those obtained in undenatured type II collagen studies. In conclusion, undenatured type II collagen and are considered a valid option for the multimodal approach to the management of OA and for improving activity during intense exercise, but more studies are needed to conclude whether or not it prevents OA in dogs.
在近几十年骨关节炎（OA）的多模式管理中，一直提倡使用饲料补充剂来维持关节软骨。本范围综述的目的是介绍在兽医文献中发现的关于未变性II型胶原蛋白和在犬类中的使用结果，特别是其在有OA临床症状的犬类、剧烈运动后的健康犬类或易患OA疾病的犬类中的使用。为此，使用电子数据库PubMed、科学网和谷歌学术进行了文献综述，本综述共纳入26条记录：14条评估未变性II型胶原蛋白，10条评估，2条评估未变性II型胶原蛋白和的组合。对记录的综述表明，未变性II型胶原蛋白可减轻与OA相关的临床症状，改善总体临床状态，减轻跛行程度，增加身体活动或行动能力。由于研究发表有限以及所用产品的纯度和成分存在差异，单独评估对补充剂的反应较为复杂，但一般来说，它与其他饲料补充剂联合使用可通过减轻疼痛和减少犬类OA的临床症状而产生益处。在同一产品中两者的组合产生的结果与未变性II型胶原蛋白研究中获得的结果相似。总之，未变性II型胶原蛋白和被认为是OA多模式管理以及改善剧烈运动期间活动能力的有效选择，但需要更多研究来确定它是否能预防犬类OA。
