Boyd N F, Fishell E, Tonkin K, Mobbs B G
Ludwig Institute for Cancer Research, Toronto, Ontario, Canada.
Breast Cancer Res Treat. 1987 Oct;10(1):51-4. doi: 10.1007/BF01806135.
We have examined the association between hormone receptor concentration in primary breast cancer and the mammographic pattern of the breast in which the cancer arose. A significant association was found between the concentration of estrogen receptor and the proportion of the breast volume occupied by the radiological signs of dysplasia. Both estrogen receptor concentration and dysplasia were found to be strongly associated with age. Estrogen receptor concentration rose with increasing age, while the age of patients with extensive dysplasia was substantially less than that of patients with no dysplasia. After taking age into account, no association remained between estrogen receptor concentration and mammographic dysplasia. Age is therefore a confounding factor in this association.
我们研究了原发性乳腺癌中激素受体浓度与癌症所发生乳房的乳腺X线摄影模式之间的关联。发现雌激素受体浓度与乳房发育异常的放射学征象所占乳房体积比例之间存在显著关联。雌激素受体浓度和发育异常均与年龄密切相关。雌激素受体浓度随年龄增长而升高，而广泛发育异常患者的年龄明显低于无发育异常患者。在考虑年龄因素后，雌激素受体浓度与乳腺X线摄影显示的发育异常之间不再存在关联。因此，年龄是这种关联中的一个混杂因素。
