Hinton C P, Williams M R, Roebuck E J, Blamey R W, Glaves J, Nicholson R I, Griffiths K
Br J Surg. 1984 May;71(5):357-9. doi: 10.1002/bjs.1800710515.
We have studied the relationship between mammographic parenchymal pattern of the breast and oestrogen receptor (ER) status in the primary tumour in 337 patients with operable invasive breast cancer, and the response to endocrine therapy in patients subsequently developing secondary disease. Patients with dysplastic (DY) parenchymal pattern are significantly more likely to develop tumours which are ER-positive. In 92 patients who subsequently developed secondary disease, those whose primary tumour arose in a DY pattern breast were significantly more likely to respond to endocrine therapy irrespective of their ER status.
我们研究了337例可手术浸润性乳腺癌患者乳腺钼靶实质模式与原发肿瘤中雌激素受体（ER）状态之间的关系，以及随后发生继发性疾病的患者对内分泌治疗的反应。发育异常（DY）实质模式的患者发生ER阳性肿瘤的可能性显著更高。在随后发生继发性疾病的92例患者中，原发肿瘤发生在DY模式乳腺的患者，无论其ER状态如何，对内分泌治疗有反应的可能性显著更高。
