Pan Qingqing, Luo Yaping, Cao Xinxin, Li Jian, Li Fang
Department of Nuclear Medicine, Chinese Academy of Medical Sciences and Peking Union Medical College Hospital, Beijing 100730, China.
Beijing Key Laboratory of Molecular Targeted Diagnosis and Therapy in Nuclear Medicine, Beijing 100730, China.
Diagnostics (Basel). 2023 Feb 24;13(5):871. doi: 10.3390/diagnostics13050871.
Two patients with a history of multiple myeloma experienced a recurrence of the disease.F-FDG PET/CT revealed prominent extramedullary disease as well as multi-foci in the bone marrow, both with increased FDG uptake. However, on Ga-Pentixafor PET/CT, all the myeloma lesions showed significantly lower tracer uptake in comparison with F-FDG PET. This false-negative result of recurrent multiple myeloma with extramedullary disease may be a potential limitation of Ga-Pentixafor in assessing multiple myeloma.
两名有多发性骨髓瘤病史的患者出现了疾病复发。F-FDG PET/CT显示有明显的髓外病变以及骨髓中的多个病灶，两者的FDG摄取均增加。然而，在镓-喷替沙福PET/CT上，与F-FDG PET相比，所有骨髓瘤病灶的示踪剂摄取均显著降低。这种伴有髓外病变的复发性多发性骨髓瘤的假阴性结果可能是镓-喷替沙福在评估多发性骨髓瘤方面的一个潜在局限性。
