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血常规衍生的炎症标志物与住院时间延长相关,是胸外伤患者气胸风险的预测指标。

Blood Count-Derived Inflammatory Markers Correlate with Lengthier Hospital Stay and Are Predictors of Pneumothorax Risk in Thoracic Trauma Patients.

作者信息

Vunvulea Vlad, Melinte Răzvan Marian, Brinzaniuc Klara, Suciu Bogdan Andrei, Ivănescu Adrian Dumitru, Hălmaciu Ioana, Incze-Bartha Zsuzsanna, Pastorello Ylenia, Trâmbițaș Cristian, Mărginean Lucian, Kaller Réka, Kassas Ahmad, Hogea Timur

机构信息

Doctoral School of Medicine and Pharmacy, George Emil Palade University of Medicine, Pharmacy, Sciences and Technology of Targu Mures, 540142 Targu Mures, Romania.

Department of Radiology, Mures County Emergency Hospital, 540136 Targu Mures, Romania.

出版信息

Diagnostics (Basel). 2023 Mar 2;13(5):954. doi: 10.3390/diagnostics13050954.

Abstract

(1) Background: Trauma is one of the leading causes of death worldwide, with the chest being the third most frequent body part injured after abdominal and head trauma. Identifying and predicting injuries related to the trauma mechanism is the initial step in managing significant thoracic trauma. The purpose of this study is to assess the predictive capabilities of blood count-derived inflammatory markers at admission. (2) Materials and Methods: The current study was designed as an observational, analytical, retrospective cohort study. It included all patients over the age of 18 diagnosed with thoracic trauma, confirmed with a CT scan, and admitted to the Clinical Emergency Hospital of Targu Mureş, Romania. (3) Results: The occurrence of posttraumatic pneumothorax is highly linked to age ( = 0.002), tobacco use ( = 0.01), and obesity ( = 0.01). Furthermore, high values of all hematological ratios, such as the NLR, MLR, PLR, SII, SIRI, and AISI, are directly associated with the occurrence of pneumothorax ( < 0.001). Furthermore, increased values of the NLR, SII, SIRI, and AISI at admission predict a lengthier hospitalization ( = 0.003). (4) Conclusions: Increased neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), platelet-to-lymphocyte ratio (PLR), systemic inflammatory index (SII), aggregate inflammatory systemic index (AISI), and systemic inflammatory response index (SIRI) levels at admission highly predict the occurrence of pneumothorax, according to our data.

摘要

(1) 背景:创伤是全球主要死因之一,胸部是继腹部和头部创伤后第三大最常受伤的身体部位。识别和预测与创伤机制相关的损伤是处理严重胸部创伤的第一步。本研究的目的是评估入院时血常规衍生的炎症标志物的预测能力。(2) 材料与方法:本研究设计为一项观察性、分析性、回顾性队列研究。纳入了所有18岁以上诊断为胸部创伤、经CT扫描确诊并入住罗马尼亚特尔古穆列什临床急诊医院的患者。(3) 结果:创伤后气胸的发生与年龄(P = 0.002)、吸烟(P = 0.01)和肥胖(P = 0.01)高度相关。此外,所有血液学比值,如中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、血小板与淋巴细胞比值(PLR)、全身炎症指数(SII)、全身炎症反应指数(SIRI)和聚集性全身炎症指数(AISI)的高值都与气胸的发生直接相关(P < 0.001)。此外,入院时NLR、SII、SIRI和AISI值的升高预示住院时间更长(P = 0.003)。(4) 结论:根据我们的数据,入院时中性粒细胞与淋巴细胞比值(NLR)、单核细胞与淋巴细胞比值(MLR)、血小板与淋巴细胞比值(PLR)、全身炎症指数(SII)、聚集性全身炎症指数(AISI)和全身炎症反应指数(SIRI)水平的升高高度预示气胸的发生。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/edfb/10000372/9b58bfce27df/diagnostics-13-00954-g001.jpg

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